4-Diethylaminobenzaldehyde
- Product Name
- 4-Diethylaminobenzaldehyde
- CAS No.
- 120-21-8
- Chemical Name
- 4-Diethylaminobenzaldehyde
- Synonyms
- DEAB;4-(N,N-DIETHYLAMINO)BENZALDEHYDE;N,N-Diethylaminobenzaldehyde;4-DiethyL;DEAB - NSC 8782;AKOS BBS-00003202;4-Diethylaminobenzal;LABOTEST-BB LT00924385;p-Diethylaminobenzaldehyd;4-DIETHYLAMINOBENZALDEHYDE
- CBNumber
- CB5127559
- Molecular Formula
- C11H15NO
- Formula Weight
- 177.24
- MOL File
- 120-21-8.mol
4-Diethylaminobenzaldehyde Property
- Melting point:
- 37-41 °C(lit.)
- Boiling point:
- 174 °C7 mm Hg(lit.)
- Density
- 1.03 g/cm3
- refractive index
- 1.5302 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Store below +30°C.
- solubility
- 2.5g/l
- pka
- 3.36±0.32(Predicted)
- form
- Coarse Crystals, Chunks or Crystalline Solid
- color
- Brown to green to black
- Water Solubility
- insoluble
- Sensitive
- Air Sensitive
- BRN
- 511102
- CAS DataBase Reference
- 120-21-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzaldehyde, 4-(diethylamino)-(120-21-8)
- EPA Substance Registry System
- Benzaldehyde, 4-(diethylamino)- (120-21-8)
Safety
- Hazard Codes
- Xi,N,Xn
- Risk Statements
- 36/37/38-50/53-21/22
- Safety Statements
- 26-36-61-60-36/37
- WGK Germany
- 2
- RTECS
- CU5612850
- TSCA
- Yes
- HS Code
- 29223990
- Toxicity
- mouse,LD50,intraperitoneal,700mg/kg (700mg/kg),National Technical Information Service. Vol. OTS0534444,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D86256
- Product name
- 4-Diethylaminobenzaldehyde
- Purity
- 99%
- Packaging
- 100g
- Price
- $60.9
- Updated
- 2025/07/31
- Product number
- D0463
- Product name
- 4-Diethylaminobenzaldehyde
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- D0463
- Product name
- 4-Diethylaminobenzaldehyde
- Purity
- >99.0%(GC)(T)
- Packaging
- 100g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D0463
- Product name
- 4-Diethylaminobenzaldehyde
- Purity
- >99.0%(GC)(T)
- Packaging
- 500g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- 139230
- Product name
- 4-(Diethylamino)benzaldehyde
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $215
- Updated
- 2021/12/16
4-Diethylaminobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
dark brown to green coarse crystals or
Uses
4-Diethylaminobenzaldehyde is used in the preparation of 5-(4-diethylamino-benzylidene)-selenazolidine-2,4-dione by using aqueous methylamine as a reagent.
Definition
ChEBI: A member of the class of benzaldehydes carrying a diethylamino substituent at position 4.
Synthesis
459-57-4
109-89-7
120-21-8
GENERAL STEPS: 4-Fluorobenzaldehyde (2.5 g, 20 mmol), diethylamine (5.12 g, 70 mmol), potassium carbonate (4.15 g), dimethylsulfoxide (25.0 mL), and Aliquat-336 (0.05 mL) were added to a 100 mL single-necked flask equipped with a stirrer and condenser. The reaction mixture was stirred at 95°C for 72 hours and subsequently cooled to room temperature. Upon addition of ice water, a yellow precipitate precipitated. The crude product was washed 2-3 times with cold water and recrystallized by ethanol to give N,N-diethyl-4-aminobenzaldehyde as a yellow solid. Yield: 92%. Elemental analysis calculated values (C11H15NO): C, 74.54; H, 8.53; N, 7.90; measured values: C, 74.67; H, 8.58; N, 7.85. 1H NMR (500 MHz, CDCl3, ppm) δ 9.71 (s, 1H), 7.72 (q, 2H), 6.69 (d, J = 8.8 Hz, 2H) , 3.46 (q, 4H), 1.24 (t, 6H). Step 2: Potassium metal (0.78 g, 20 mmol) was added to tert-butanol (11.3 mL, 120 mmol) in a 50 mL single-neck flask equipped with a condenser. After the potassium was fully reacted, 4-methylpyridine (0.975 mL, 10 mmol) and N,N-diethyl-4-aminobenzaldehyde (1.77 g, 10 mmol) were added. The mixture was heated with stirring at 80°C for 2 hours. After evaporation to remove the tert-butanol, 200 mL of dichloromethane was added and washed once with 200 mL of ice water. The aqueous phase was extracted three times with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, the solvent was evaporated and the crude product was recrystallized from toluene. Yield: 86%.1H NMR (500 MHz, DMSO, ppm) δ 8.43 (d, J = 5.2 Hz, 2H), 7.42 (t, J = 8.8 Hz, 2H), 7.23 (d, J = 5.4 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 6.27-6.66 (m, 2H), 3.39 (m, 4H), 1.13 (m, 4H). 4H), 1.13 (t, 6H).13C NMR (500 MHz, CDCl3, ppm) δ 148.56-146.96 (m, py), 134.57 (s, py), 128.86 (s, benzene), 120.51-119.95 (d, benzene), 111.56 (s, CH=CH), 44.47 (s, CH2), 12.62 (d, J = 8.7 Hz, 2H), 6.27-6.66 (m, 2H), 3.39 (m, 2H), 3.39 (m, 6H). CH2), 12.62 (s, CH3). Calculated elemental analysis (C17H20N2, EI-MS: 253.3): C, 80.91; H, 7.99; N, 11.10; measured: C, 80.76; H, 7.91; N, 11.01. IR (KBr, cm-1): 3026 w, 2974 m, 1581 s, 1520 vs, 1408 m, 1355 m. 1329 w, 1272 m, 1185 m, 1158 m, 1074 w, 972 w, 818 m, 795 m, 518 w. Melting Point: 258°C.
References
[1] Dyes and Pigments, 2015, vol. 120, p. 175 - 183
[2] Journal of Molecular Structure, 2007, vol. 829, # 1-3, p. 202 - 207
[3] Journal of Materials Chemistry, 2012, vol. 22, # 33, p. 16927 - 16932
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 19, p. 8483 - 8492,10
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 19, p. 8483 - 8492
4-Diethylaminobenzaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Diethylaminobenzaldehyde manufacturers
- Product
- 4-Diethylaminobenzaldehyde 120-21-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Diethylaminobenzaldehyde 120-21-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- 4-Diethylaminobenzaldehyde 120-21-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-25