5-Nitro-2-indanone
Application- Product Name
- 5-Nitro-2-indanone
- CAS No.
- 116530-60-0
- Chemical Name
- 5-Nitro-2-indanone
- Synonyms
- 5-nitro-1H-inden-2(3H)-one;5-nitro-1,3-dihydroinden-2-one;5-NITRO-2-INDANONE;5-NITRO-INDAN-2-ONE;5-Nitro-2-Indanone(WX625103);5-nitro-2,3-dihydro-1H-inden-2-one;2H-Inden-2-one, 1,3-dihydro-5-nitro-
- CBNumber
- CB5130816
- Molecular Formula
- C9H7NO3
- Formula Weight
- 177.16
- MOL File
- 116530-60-0.mol
5-Nitro-2-indanone Property
- Boiling point:
- 340.6±42.0 °C(Predicted)
- Density
- 1.396±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C9H7NO3/c11-9-4-6-1-2-8(10(12)13)3-7(6)5-9/h1-3H,4-5H2
- InChIKey
- VSEBFWRYDORZJI-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=C([N+]([O-])=O)C=C2)CC1=O
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N496353
- Product name
- 5-Nitro-2-indanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-B1154
- Product name
- 5-Nitro-1H-inden-2(3H)-one
- Purity
- 96.83%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- OR912539
- Product name
- 5-Nitro-2-indanone
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- CS-B1154
- Product name
- 5-Nitro-1H-inden-2(3H)-one
- Purity
- 96.83%
- Packaging
- 5g
- Price
- $193
- Updated
- 2021/12/16
- Product number
- CS-B1154
- Product name
- 5-Nitro-1H-inden-2(3H)-one
- Purity
- 96.83%
- Packaging
- 10g
- Price
- $340
- Updated
- 2021/12/16
5-Nitro-2-indanone Chemical Properties,Usage,Production
Application
5-Nitro-2-indanone is a pharmaceutical intermediate that can be prepared from 2-indanol in four steps or from indanol by nitration followed by oxidation.
Synthesis
615-13-4
116530-60-0
Add 5.6 g of 2-indanone and 40 mL of chloroform to a 250 mL single neck flask. Measure 13 mL of 95% fuming nitric acid. Both were cooled in a cryogenic bath at a temperature below -20°C. The cooled 2-indanone was slowly added to the cooled fuming nitric acid. The dropwise addition process was continued for 40 minutes under vigorous stirring. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: chloroform:methanol=100:1, product Rf=0.64, 2-indanone Rf=0.79). After dropwise addition was complete, the reaction was continued at -20°C for 20 min to ensure complete reaction. The reaction was quenched with 60 mL of 10% sodium hydroxide solution mixed with ice water. The reaction mixture was layered in a dispensing funnel. The upper aqueous phase was extracted with chloroform (3 x 30 mL). The organic phases were combined and washed with saturated saline until neutral. The organic solvent was evaporated using a rotary evaporator to give a yellow solid. Recrystallized by ethyl acetate and cyclohexane and cooled to give reddish brown crystals. Upon filtration, 3.8 g of 5-nitro-2-indanone was obtained in 49.5% yield with a melting point of 141-143°C. The crystals were purified by filtration.
References
[1] Journal of the American Chemical Society, 1997, vol. 119, # 52, p. 12722 - 12726
[2] Patent: CN105315204, 2016, A. Location in patent: Paragraph 0028; 0032; 0033
[3] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 738 - 747
[4] Chemische Berichte, 1899, vol. 32, p. 28,31
5-Nitro-2-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
5-Nitro-2-indanone Suppliers
- Tel
- 021-11111111 11111111111
- Fax
- qq:546919421
- 546919421@qq.com
- Country
- China
- ProdList
- 3518
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
View Lastest Price from 5-Nitro-2-indanone manufacturers
- Product
- 5-Nitro-2-indanone 116530-60-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-16
- Product
- 5-Nitro-2-indanone 116530-60-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-23