ChemicalBook > CAS DataBase List > 2,4-Dinitrofluorobenzene

2,4-Dinitrofluorobenzene

Product Name
2,4-Dinitrofluorobenzene
CAS No.
70-34-8
Chemical Name
2,4-Dinitrofluorobenzene
Synonyms
DNF;DNPF;DNFB;1-FLUORO-2,4-DINITROBENZENE;FDNB;4-fluoro-1,2-dinitrobenzene;Dinitrofluorobenzene;Fluorodinitrobenzene;2,4-DINITRO-1-FLUOROBENZENE;2,4-Dnfb
CBNumber
CB9442373
Molecular Formula
C6H3FN2O4
Formula Weight
186.1
MOL File
70-34-8.mol
More
Less

2,4-Dinitrofluorobenzene Property

Melting point:
25-27 °C (lit.)
Boiling point:
178 °C/25 mmHg (lit.)
Density 
1.482 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.569(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
chloroform: 0.1 g/mL, clear
form 
Liquid or Low Melting Crystals
color 
Yellow to brownish
Specific Gravity
1.482
Water Solubility 
400 mg/L (25 ºC)
Merck 
14,4172
BRN 
398632
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
70-34-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA Substance Registry System
2,4-Dinitrofluorobenzene (70-34-8)
More
Less

Safety

Hazard Codes 
C,T,Xn
Risk Statements 
22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
Safety Statements 
22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
CZ7800000
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29049085
Hazardous Substances Data
70-34-8(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
42085
Product name
1-Fluoro-2,4-dinitrobenzene
Purity
purum p.a., ≥98.0% (GC)
Packaging
50g
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
42085
Product name
1-Fluoro-2,4-dinitrobenzene
Purity
purum p.a., ≥98.0% (GC)
Packaging
250g
Price
$412
Updated
2024/03/01
TCI Chemical
Product number
A5512
Product name
2,4-Dinitrofluorobenzene [for HPLC Labeling]
Purity
>99.0%(GC)
Packaging
5g
Price
$48
Updated
2023/06/20
TCI Chemical
Product number
A5512
Product name
2,4-Dinitrofluorobenzene [for HPLC Labeling]
Purity
>99.0%(GC)
Packaging
25g
Price
$139
Updated
2023/06/20
Alfa Aesar
Product number
A11871
Product name
1-Fluoro-2,4-dinitrobenzene, 99%
Packaging
5g
Price
$37.6
Updated
2023/06/20
More
Less

2,4-Dinitrofluorobenzene Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.

Uses

1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.

Definition

ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.

General Description

Clear yellow crystals or yellow crystalline solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Fire Hazard

2,4-Dinitrofluorobenzene is probably combustible.

Contact allergens

DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata

Biochem/physiol Actions

1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing.

Safety Profile

Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.

Purification Methods

Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]

2,4-Dinitrofluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,4-Dinitrofluorobenzene Suppliers

BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60

70-34-8, 2,4-DinitrofluorobenzeneRelated Search:


  • 2,4-Dinitrofluorobenzene,98%
  • 2,4-Dinitrofluoroben
  • 4-Dinitrofluorobenzene
  • 4-Fluoro-1,3-dinitrobenzene
  • NSC 33519
  • (T)2,4-DINITRO-1-FLUOROBENZENE
  • 1,1′-Bis(1-dinaphthylphosphino)ferrocene
  • 1-Fluoro-2,4-dinitrobenzene 〔2,4-Dinitrofluorobenzene〕
  • 2,4-Dinitrofluorobenzene≥ 99% (HPLC)
  • 1-Fluoro-2,4-dinitrobenzene(DNFB、DNPF、FDNB)
  • Zhou′s Ligand
  • 1-fluoro-2,4-dinitro-benzen
  • Benzene, 2,4-dinitro-1-fluoro-
  • Dinitrofluorobenzene
  • Fluoro-2,4-Dinitrobenzene
  • Fluorodinitrobenzene
  • 1,3-DINITRO-4-FLUOROBENZENE
  • 2,4-dinitro-1-fluoro-benzen
  • 2,4-Dinitrobenzenefluoride
  • 2,4-Dinitrophenyl fluoride
  • 2,4-Dnfb
  • 2,4-DINITRO-1-FLUOROBENZENE
  • 2,4-DINITROFLUOROBENZENE
  • 1-FLUORO-2,4-DINITROBENZENE
  • 1,2,4-Fluorodinitrobenzene
  • DNPF
  • DNF OR DNFB
  • Sanger's
  • Benzene, 1-fluoro-2,4-dinitro-
  • DINITROFLUORBENZENE
  • 2,4-Dinitrofluorobenzene [for HPLC Labeling]
  • DNF
  • DNFB
  • FDNB
  • SANGER REAGENT
  • SANGER'S REAGENT
  • 2,4-DINITROFLUOROBENZENE APPROX. 99%
  • 2,2-Dinitrofluorobenzene
  • 2,4-Dinitrofluorobenzene99%
  • 1-Fluoro-2,4-DinitrobenzeneGr
  • 1-Fluoro-2,4-DinitrobenzeneGr-(Dnpf,Fdnb,2,4-Dinitro-1-Fluorobenzene,Sanger'SReagent)
  • 2,4-Dinitrofluorobenzene 99%
  • 2,4-Dinitriofluorobenzene
  • 4-fluoro-1,2-dinitrobenzene
  • 1-FLUORO-2,4-DINITROBENZENE extrapure AR
  • 2,4-Dinitro-1-fluorobenzene, DNFB, DNPF, FDNB, Sanger reagent
  • 2,4-DINITROFLUOROBENZENE (SANGER''S REAGENT)
  • 2,4-Dinitrofluorobenzene &gt
  • 2,4-Dinitrofluorobenzene[forHPLCLabeling]&gt
  • 1-Fluoro-2
  • 2,4-DINITROFLUOROBENZENE AR
  • 1-Fluoro-2,4-dinitrobenzene, GR 99%+
  • 1-Fluoro-2,4-Dinitrobenzene (FDNB) extrapure AR, 99%
  • 2,4-dinitrofluorotoluene
  • 70-34-8
  • FNO22C6H3
  • C6H3NO22F
  • C6H3FN2O4