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anhydrotetrodotoxin

Product Name
anhydrotetrodotoxin
CAS No.
13072-89-4
Chemical Name
anhydrotetrodotoxin
Synonyms
9-anhydro-TTX;4,9-Anhydro-TTX;anhydrotetrodotoxin;4,9-Anhydrotetrodotoxin;4,9-Dideoxy-4β,9β-epoxytetrodotoxin;(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin;4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin;(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol;6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-
CBNumber
CB51328746
Molecular Formula
C11H15N3O7
Formula Weight
301.25
MOL File
13072-89-4.mol
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anhydrotetrodotoxin Property

storage temp. 
-20°
solubility 
Soluble in Ethanol (up to 10 mg/ml).
form 
A solid or film
color 
Colorless
Water Solubility 
Soluble to 1 mg/ml in water
Stability:
Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19084
Product name
4,9-Anhydrotetrodotoxin
Purity
≥98%
Packaging
100μg
Price
$242
Updated
2024/03/01
Tocris
Product number
6159
Product name
4,9-Anhydrotetrodotoxin
Purity
≥98%(HPLC)
Packaging
100U
Price
$227
Updated
2021/12/16
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anhydrotetrodotoxin Chemical Properties,Usage,Production

Description

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.

storage

Store at -20°C

References

[1] CHRISTIAN ROSKER. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel.[J]. American journal of physiology. Cell physiology, 2007, 293 2: C783-9. DOI:10.1152/ajpcell.00070.2007
[2] NICHOLAS DENOMME . The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6[J]. Neuroscience Letters, 2020, 724: Article 134853. DOI:10.1016/j.neulet.2020.134853

anhydrotetrodotoxin Preparation Products And Raw materials

Raw materials

Preparation Products

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anhydrotetrodotoxin Suppliers

China 18 United Kingdom 1 United States 4 USA 1 Global 24
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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sales@chemegen.com
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Energy Chemical
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TargetMol Chemicals Inc.
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Cayman Chemical Company
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Alomone Labs
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13072-89-4, anhydrotetrodotoxinRelated Search:

(+/-)-Verapamil hydrochloride 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide A 967079 VERATRIDINE (TETRAHYDRO-2H-PYRAN-3-YL)METHANAMINE HYDROCHLORIDE METHYL-(TETRAHYDRO-PYRAN-3-YLMETHYL)-AMINE 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE 4-(2-AMINOETHYL)TETRAHYDROPYRAN (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL anhydrotetrodotoxin

  • anhydrotetrodotoxin
  • (8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin
  • 4,9-Anhydrotetrodotoxin
  • 4,9-Dideoxy-4β,9β-epoxytetrodotoxin
  • (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
  • 6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-
  • 9-anhydro-TTX
  • 4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin
  • 4,9-Anhydro-TTX
  • 13072-89-4