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Adjudin

Product Name
Adjudin
CAS No.
252025-52-8
Chemical Name
Adjudin
Synonyms
AF-2364;CS-2018;Adjudin;Adjudin, AF-2364;AF-2364;AF 2364;AF2364;1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide;1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide;1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide USP/EP/BP;1-(2,4-Dichloro-benzyl)-1H-indazole-3-carboxylic acid hydrazide;1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid hydrazide
CBNumber
CB51331593
Molecular Formula
C15H12Cl2N4O
Formula Weight
335.19
MOL File
252025-52-8.mol
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Adjudin Property

Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:34.56(Max Conc. mg/mL);103.11(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.5(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.05(Max Conc. mg/mL);0.15(Max Conc. mM)
form 
A crystalline solid
pka
11.88±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22939
Product name
Adjudin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22939
Product name
Adjudin
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22939
Product name
Adjudin
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
22939
Product name
Adjudin
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
AK Scientific
Product number
3333CR
Product name
1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide
Packaging
25mg
Price
$691
Updated
2021/12/16
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Adjudin Chemical Properties,Usage,Production

Biological Activity

Adjudin (AF-2364) is an effective male contraceptive and a potent blocker of Cl? channels. It has anti-inflammatory properties by inhibiting NF-κB p65 nuclear translocation and DNA binding activity and ERK MAPK phosphorylation.

in vitro

Adjudin is a potent blocker of Cl - channels: disrupting Cl - ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro . Adjudin (ADD) is a mitochondria inhibitor. Adjudin is a molecule that mediates adherens junction disruption at the Sertoli-germ cell interface. To investigate the effect of Adjudin on cancer cells, more than ten different types of human or mice cancer cell lines are treated with increasing concentrations of Adjudin and the cell proliferation is measured by the modified MTT assay. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC 50 of Adjudin is determined to be 58.0 μM, 13.8 μM, 72.3 μM and 52.7 μM against SGC -7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, res pectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC 50 of Adjudin in A549 cells and PC3 cells is 63.1 μM and 93.0 μM, respectively. For WI -38 and BPH-1 cells, the IC 50 of Adjudin can be observed at more than 300 μM and 200 μM, respectively, which is about 5 times and 2 times more than that for the cancer cell lines A549 and PC3.

in vivo

To determine whether Adjudin can inhibit lung and prostate cancer growth in vivo, the effect of Adjudin is tested in a subcutaneous model of lung and prostate cancer. Human lung carcinoma cells A549 and prostate carcinoma cells PC3 are injected into athymic nude mice subdermally at the lower back site respectively. Mice are then randomized into two treatment groups with similar mean tumor sizes: Adjudin and vehicle (control). Approximately 2 weeks after tumor inoculation Adjudin is injected intraperitoneally once every three days in lung carcinoma cells and every other day in prostate carcinoma cells at 100 mg/kg. Adjudin treatment can be well tolerated in rodent. And Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P =0.006 in the prostate carcinoma cells PC3).

target

TargetValue
Cl? channel
()
NF-κB
()
ERK
()

Adjudin Preparation Products And Raw materials

Raw materials

Preparation Products

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Adjudin Suppliers

China 77 India 1 United States 11 Global 89
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Shanghai Run-Biotech Co., Ltd.
Tel
021-57171705 13817537615
Fax
QQ3095748324
Email
sales@run-biotech.com
Country
China
ProdList
2596
Advantage
58
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5945
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4992
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Hunan Cangood Medical Technology Ltd.
Tel
400-026-9899
Fax
+86-731-86905278
Country
China
ProdList
71
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
Advantage
55
Candia Pharmatech Co. , Ltd.
Tel
+86-371-55216238
Fax
+86-371-86615086
Country
China
ProdList
286
Advantage
60
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View Lastest Price from Adjudin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide 252025-52-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Dideu Industries Group Limited
Product
1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide 252025-52-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100Tons min
Release date
2021-06-11

252025-52-8, AdjudinRelated Search:

TSH PIERICIDIN A Testosterone enanthate

  • 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide
  • CS-2018
  • AF-2364
  • 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide
  • Adjudin, AF-2364
  • Adjudin
  • 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid hydrazide
  • 1-(2,4-Dichloro-benzyl)-1H-indazole-3-carboxylic acid hydrazide
  • AF-2364;AF 2364;AF2364
  • 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide
  • 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide USP/EP/BP
  • AF 2364,Mitochondrial Metabolism,AF2364,Cl? Channels,Adjudin,inhibit,Inhibitor,Chloride Channel
  • 252025-52-8
  • Inhibitors
  • pharmaceutical intermedaite