DMP 777

Product Name: DMP 777
CAS No.: 157341-41-8
Chemical Name: DMP 777
Synonyms: DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
CBNumber: CB51333719
Molecular Formula: C31H40N4O6
Formula Weight: 564.67
MOL File: 157341-41-8.mol

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DMP 777 Property

Density: 1.227
storage temp.: Store at -20°C
solubility: DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0355
Product name: DMP777
Purity: 99.13%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB167347
Product name: (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide
Packaging: 2mg
Price: $300
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001205
Product name: L-694458
Purity: 95.00%
Packaging: 5MG
Price: $496.38
Updated: 2021/12/16

ChemScene

Product number: CS-0355
Product name: DMP777
Purity: 99.13%
Packaging: 25mg
Price: $510
Updated: 2021/12/16

ChemScene

Product number: CS-0355
Product name: DMP777
Purity: 99.13%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

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DMP 777 Chemical Properties,Usage,Production

Biological Activity

DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).

in vivo

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.

target

Human leukocyte elastase (HLE)

DMP 777 Preparation Products And Raw materials

Raw materials

Preparation Products

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DMP 777 Suppliers

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157341-41-8, DMP 777Related Search:

N,N'-Ethylenebis(stearamide) Sulfanilamide

DMP 777

(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide

(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)

1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-

(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide

(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe

L 694458

L-694458; DMP-777; DMP777

(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)

157341-41-8

C31H40N4O6