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DMP 777

Product Name
DMP 777
CAS No.
157341-41-8
Chemical Name
DMP 777
Synonyms
DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
CBNumber
CB51333719
Molecular Formula
C31H40N4O6
Formula Weight
564.67
MOL File
157341-41-8.mol
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DMP 777 Property

Density 
1.227
storage temp. 
Store at -20°C
solubility 
DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0355
Product name
DMP777
Purity
99.13%
Packaging
10mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB167347
Product name
(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide
Packaging
2mg
Price
$300
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001205
Product name
L-694458
Purity
95.00%
Packaging
5MG
Price
$496.38
Updated
2021/12/16
ChemScene
Product number
CS-0355
Product name
DMP777
Purity
99.13%
Packaging
25mg
Price
$510
Updated
2021/12/16
ChemScene
Product number
CS-0355
Product name
DMP777
Purity
99.13%
Packaging
5mg
Price
$200
Updated
2021/12/16
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DMP 777 Chemical Properties,Usage,Production

Biological Activity

DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).

in vivo

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.

target

Human leukocyte elastase (HLE)

DMP 777 Preparation Products And Raw materials

Raw materials

Preparation Products

157341-41-8, DMP 777Related Search:


  • DMP 777
  • (2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide
  • (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)
  • 1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-
  • (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide
  • (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe
  • L 694458
  • L-694458; DMP-777; DMP777
  • (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
  • 157341-41-8
  • C31H40N4O6