DMP 777
- Product Name
- DMP 777
- CAS No.
- 157341-41-8
- Chemical Name
- DMP 777
- Synonyms
- DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
- CBNumber
- CB51333719
- Molecular Formula
- C31H40N4O6
- Formula Weight
- 564.67
- MOL File
- 157341-41-8.mol
DMP 777 Property
- Density
- 1.227
- storage temp.
- Store at -20°C
- solubility
- DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)
N-Bromosuccinimide Price
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FB167347
- Product name
- (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide
- Packaging
- 2mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- KIN0001205
- Product name
- L-694458
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.38
- Updated
- 2021/12/16
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 25mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
DMP 777 Chemical Properties,Usage,Production
Biological Activity
DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).
in vivo
DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.
target
Human leukocyte elastase (HLE)