paraherquamide
- Product Name
- paraherquamide
- CAS No.
- 77392-58-6
- Chemical Name
- paraherquamide
- Synonyms
- VM 29919;paraherquamide;(-)-Paraherquamide A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
- CBNumber
- CB51336725
- Molecular Formula
- C28H35N3O5
- Formula Weight
- 493.59
- MOL File
- 77392-58-6.mol
paraherquamide Property
- Melting point:
- 244-247° (dec)
- alpha
- D22 -28° (c = 0.43 in methanol)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- White to off-white powder.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26685
- Product name
- Paraherquamide A
- Packaging
- 1mg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- 26685
- Product name
- Paraherquamide A
- Packaging
- 5mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- P193278
- Product name
- ParaherquamideA
- Packaging
- 0.5mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- INB0004348
- Product name
- PARAHERQUAMIDE A
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $538.65
- Updated
- 2021/12/16
paraherquamide Chemical Properties,Usage,Production
Description
Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).
Uses
Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.
Uses
Paraherquamide A is a selective, competitive, cholinergic antagonist.
References
[1] ALAN P ROBERTSON. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle.[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 302 1: 853-860. DOI: 10.1124/jpet.102.034272
[2] RALF NAUEN Klaus T Ulrich Ebbinghaus. Ligands of the nicotinic acetylcholine receptor as insecticides?[J]. Pest Management Science, 1999, 55 5: 608-610. DOI: 10.1002/(sici)1096-9063(199905)55:5<608::aid-ps967>3.0.co;2-y
[3] J G ONDEYKA. Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity.[J]. Journal of Antibiotics, 1990, 43 11: 1375-1379. DOI: 10.7164/antibiotics.43.1375
[4] D.A. OSTLIND. Efficacy of paraherquamide against immature Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus)[J]. Research in veterinary science, 1990, 48 2: Pages 260-261. DOI: 10.1016/s0034-5288(18)31003-8
[5] W L SHOOP. Acute toxicity of paraherquamide and its potential as an anthelmintic.[J]. American journal of veterinary research, 1992, 53 11: 2032-2034.
paraherquamide Preparation Products And Raw materials
Raw materials
Preparation Products
paraherquamide Suppliers
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9650
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- +86-86-57188162785 13606544505
- Fax
- +86-571-81906939
- lucy@verychem.com
- Country
- China
- ProdList
- 1164
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 9881
- Advantage
- 58
- Tel
- 58896805
- 7993601name@qq.com
- Country
- CHINA
- ProdList
- 6620
- Advantage
- 58
- Tel
- 15317051735
- zhaojing@wytsci.com
- Country
- China
- ProdList
- 9980
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@verychem.com
- Country
- China
- ProdList
- 528
- Advantage
- 51