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paraherquamide

Product Name
paraherquamide
CAS No.
77392-58-6
Chemical Name
paraherquamide
Synonyms
VM 29919;paraherquamide;(-)-Paraherquamide A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
CBNumber
CB51336725
Molecular Formula
C28H35N3O5
Formula Weight
493.59
MOL File
77392-58-6.mol
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paraherquamide Property

Melting point:
244-247° (dec)
alpha 
D22 -28° (c = 0.43 in methanol)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
White to off-white powder.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26685
Product name
Paraherquamide A
Packaging
1mg
Price
$347
Updated
2024/03/01
Cayman Chemical
Product number
26685
Product name
Paraherquamide A
Packaging
5mg
Price
$1210
Updated
2024/03/01
TRC
Product number
P193278
Product name
ParaherquamideA
Packaging
0.5mg
Price
$560
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0004348
Product name
PARAHERQUAMIDE A
Purity
95.00%
Packaging
1MG
Price
$538.65
Updated
2021/12/16
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paraherquamide Chemical Properties,Usage,Production

Description

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).

Uses

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

Uses

Paraherquamide A is a selective, competitive, cholinergic antagonist.

paraherquamide Preparation Products And Raw materials

Raw materials

Preparation Products

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paraherquamide Suppliers

China 13 India 1 United Kingdom 1 United States 4 Global 19

77392-58-6, paraherquamideRelated Search:

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  • paraherquamide
  • VM 29919
  • Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
  • (-)-Paraherquamide A
  • 77392-58-6