LAVENDUSTIN C

ChemicalBook > CAS DataBase List > LAVENDUSTIN C

Product Name: LAVENDUSTIN C
CAS No.: 125697-93-0
Chemical Name: LAVENDUSTIN C
Synonyms: HDBA;COMPOUND 5;NSC 666251;LAVENDUSTIN C;Lavendustin C (HDBA);5-(2,5-DIHYDROXYBENZYLAMINO)SALICYLIC ACID;5-(N-2,5-DIHYDROXYBENZYL)AMINOSALICYLIC ACID;5-(N-2',5'-DIHYDROXYBENZYL)AMINOSALICYLIC ACID;N-(2',5'-DIHYDROXYBENZYL)-5-AMINOSALICYLIC ACID;2-hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid
CBNumber: CB5135705
Molecular Formula: C14H13NO5
Formula Weight: 275.26
MOL File: 125697-93-0.mol

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LAVENDUSTIN C Property

Melting point:: 193-195°C dec.
Boiling point:: 597.5±50.0 °C(Predicted)
Density: 1.551±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: soluble
form: solid
pka: 2.32±0.10(Predicted)
color: Light Beige to Brown
Stability:: Hygroscopic

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010329
Product name: Lavendustin C
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10010329
Product name: Lavendustin C
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 10010329
Product name: Lavendustin C
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 10010329
Product name: Lavendustin C
Purity: ≥98%
Packaging: 50mg
Price: $849
Updated: 2024/03/01

TRC

Product number: D452000
Product name: 5-(2,5-Dihydroxybenzylamino)-2-hydroxybenzoicAcid
Packaging: 25mg
Price: $410
Updated: 2021/12/16

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LAVENDUSTIN C Chemical Properties,Usage,Production

Description

Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC₅₀ value of 0.012 μM. Lavendustin C also inhibits pp60^c-src(+) kinase and Ca²⁺ calmodulin-dependent kinase II with IC₅₀ values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

Chemical Properties

Brown Solid

Uses

Shows potent tyrosine kinase inhibitory activity.

Definition

ChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine.

LAVENDUSTIN C Preparation Products And Raw materials

Raw materials

Preparation Products

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LAVENDUSTIN C Suppliers

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125697-93-0, LAVENDUSTIN CRelated Search:

5-Aminosalicylic acid Salicylic acid Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate,LAVENDUSTIN C ANALOG LAVENDUSTIN B lavendustin C6 5-BENZYL-2-FURALDEHYDE LAVENDUSTIN A METHYL ESTER LAVENDUSTIN C LAVENDUSTIN C METHYL ESTER LAVENDUSTIN A

2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID

[2-HYDROXY-5-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOIC ACID

5-(2,5-DIHYDROXYBENZYLAMINO)-2-HYDROXYBENZOIC ACID

5-(2,5-DIHYDROXYBENZYLAMINO)SALICYLIC ACID

5-(N-2',5'-DIHYDROXYBENZYL)AMINOSALICYLIC ACID

5-(N-2,5-DIHYDROXYBENZYL)AMINOSALICYLIC ACID

HDBA

COMPOUND 5

LAVENDUSTIN C

N-(2',5'-DIHYDROXYBENZYL)-5-AMINOSALICYLIC ACID

2-hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid

Compound 5, HDBA, N-(2μ,5μ-Dihydroxybenzyl)-5-aminosalicylic acid, [2-Hydroxy-5-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoic acid

5-(2,5-Dihydroxybenzylamino)salicylic acid, N-(2,5-Dihydroxybenzyl)-5-aminosalicylic acid

5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid

5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxy-benzoic acid

NSC 666251

N-(2-((2-((4Z,7Z,10Z,13Z,16Z,19Z)-DOCOSA-4,7,10,13,16,19-HEXAENAMIDO)ETHYL)DISULFANYL)-2-METHYLPROPYL)NICOTINAMIDE

Lavendustin C (HDBA)

Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-

HER1,ErbB-1,EGFR,inhibit,Inhibitor,Calmodulin-dependent protein kinases,calmodulin-dependent,Src,lavendustin C,pp60,CaMK,Ca2+,Epidermal growth factor receptor,tyrosine,kinase,Calmodulin-dependent kinases

125697-93-0

Chelators

Cell Signaling and Neuroscience

Receptor Tyrosine Kinase Inhibitors

Tyrosine Kinase (TK)

Kinase/Phosphatase Biology

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Type

Enzyme Inhibitors

Cell Biology

BioChemical

Biochemicals and Reagents

Other enzyme inhibitors and activators

All Inhibitors

Inhibitors

Tyrosine Kinase Inhibitors