4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 182618-86-6
Chemical Name: 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: 1-Boc-4-(4-Nitrophenyl);1-BOC-4-(4-NITROPHENYL)-PIPERAZINE;t-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;ert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;4-(4-nitrophenyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(4-Nitrophenyl)piperazine-1-carboxylicacidtert-butylester95%;4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%
CBNumber: CB5136818
Molecular Formula: C15H21N3O4
Formula Weight: 307.34
MOL File: 182618-86-6.mol

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4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 456.6±40.0 °C(Predicted)
Density: 1.220±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.73±0.10(Predicted)
form: Solid
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00373
Product name: tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate
Purity: AldrichCPR
Packaging: 1G
Price: $68.1
Updated: 2023/06/20

TRC

Product number: B656738
Product name: 1-Boc-4-(4-Nitrophenyl)piperazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J55746
Product name: 1-Boc-4-(4-Nitrophenyl)piperazine
Packaging: 10g
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139517
Product name: tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate
Packaging: 5G
Price: $123
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0002717
Product name: 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $126
Updated: 2021/12/16

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4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

350-46-9

57260-71-6

182618-86-6

1-Fluoro-4-nitrobenzene (5 g, 35.43 mmol) and N-BOC-piperazine (6.6 g, 35.43 mmol) were dissolved in N,N-dimethylformamide (DMF, 100 mL) and potassium carbonate (14.7 g, 106.29 mmol) was added as a base. The reaction mixture was stirred at 50 °C for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The oily residue obtained was washed three times with ether to purify the product. The final product was obtained as tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate as a yellow solid (8.2 g, 95% yield). The product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 1.48 (s, 9H), 3.38-3.45 (m, 4H), 3.56-3.63 (m, 4H), 6.75-6.86 (m, 2H), 8.07-8.20 (m, 2H). Mass spectrometry (MS) analysis showed m/z 308.1 ([M+H]+), consistent with the expected molecular formula C15H21N3O4.

References

[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: WO2017/123542, 2017, A1. Location in patent: Page/Page column 398; 399
[3] Patent: CN106905245, 2017, A. Location in patent: Paragraph 0314; 0315; 0316; 0317; 0318
[4] Patent: US2003/13708, 2003, A1
[5] Patent: US2004/87575, 2004, A1

4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 86 Germany 2 India 3 United Kingdom 4 United States 12 Global 107

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View Lastest Price from 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 182618-86-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

182618-86-6, 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

TERT-BUTYL 4-(2-FLUORO-4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate 1-N-BOC-4-(3-CARBOXY-4-NITROPHENYL)PIPERAZINE TERT-BUTYL 4-(3-ACETYL-4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE tert-butyl 4-(3-methoxy-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(3-(ETHOXYCARBONYLMETHYLCARBAMOYL)-4-NITROPHENYL)PIPERAZINE METHYL 2-(BOC-PIPERAZIN-1-YL)-5-NITROBE& BUTTPARK 83\09-68

TERT-BUTYL 4-(4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-4-(4-NITROPHENYL)-PIPERAZINE

4-(4-Nitrophenyl)piperazine-1-carboxylicacidtert-butylester95%

4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%

t-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

ert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

1-Boc-4-(4-Nitrophenyl)

4-(4-nitrophenyl)-1-piperazinecarboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(4-nitrophenyl)-, 1,1-dimethylethyl ester

182618-86-6

API intermediates

170911-92-9