4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 182618-86-6
- Chemical Name
- 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-4-(4-Nitrophenyl);1-BOC-4-(4-NITROPHENYL)-PIPERAZINE;t-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;ert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate;4-(4-nitrophenyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(4-Nitrophenyl)piperazine-1-carboxylicacidtert-butylester95%;4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%
- CBNumber
- CB5136818
- Molecular Formula
- C15H21N3O4
- Formula Weight
- 307.34
- MOL File
- 182618-86-6.mol
4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 456.6±40.0 °C(Predicted)
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.73±0.10(Predicted)
- form
- Solid
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- VBP00373
- Product name
- tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $68.1
- Updated
- 2023/06/20
- Product number
- B656738
- Product name
- 1-Boc-4-(4-Nitrophenyl)piperazine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J55746
- Product name
- 1-Boc-4-(4-Nitrophenyl)piperazine
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FB139517
- Product name
- tert-Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate
- Packaging
- 5G
- Price
- $123
- Updated
- 2021/12/16
- Product number
- COR0002717
- Product name
- 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $126
- Updated
- 2021/12/16
4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
350-46-9
57260-71-6
182618-86-6
1-Fluoro-4-nitrobenzene (5 g, 35.43 mmol) and N-BOC-piperazine (6.6 g, 35.43 mmol) were dissolved in N,N-dimethylformamide (DMF, 100 mL) and potassium carbonate (14.7 g, 106.29 mmol) was added as a base. The reaction mixture was stirred at 50 °C for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The oily residue obtained was washed three times with ether to purify the product. The final product was obtained as tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate as a yellow solid (8.2 g, 95% yield). The product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 1.48 (s, 9H), 3.38-3.45 (m, 4H), 3.56-3.63 (m, 4H), 6.75-6.86 (m, 2H), 8.07-8.20 (m, 2H). Mass spectrometry (MS) analysis showed m/z 308.1 ([M+H]+), consistent with the expected molecular formula C15H21N3O4.
References
[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: WO2017/123542, 2017, A1. Location in patent: Page/Page column 398; 399
[3] Patent: CN106905245, 2017, A. Location in patent: Paragraph 0314; 0315; 0316; 0317; 0318
[4] Patent: US2003/13708, 2003, A1
[5] Patent: US2004/87575, 2004, A1
4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
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- 021-31261262/ 49 (0)17662837245
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- Product
- 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 182618-86-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08