ChemicalBook > CAS DataBase List > Selegiline hydrochloride

Selegiline hydrochloride

Product Name
Selegiline hydrochloride
CAS No.
14611-52-0
Chemical Name
Selegiline hydrochloride
Synonyms
SELEGILINE HCL;jumex;FP-OD;fpf1100;Amindan;Anipryl;eldepryl;Movergan;Plurimen;Eldeprine
CBNumber
CB5137451
Molecular Formula
C13H18ClN
Formula Weight
223.74
MOL File
14611-52-0.mol
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Selegiline hydrochloride Property

Melting point:
141-142°C
alpha 
D25 -10.8° (c = 6.48 in water)
storage temp. 
2-8°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
white
optical activity
[α]25/D 10.8°, c = 6.48 in H2O(lit.)
Water Solubility 
Soluble in water at 100mM
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H
InChIKey
IYETZZCWLLUHIJ-UHFFFAOYSA-N
SMILES
C1(=CC=CC=C1)CC(C)N(C)CC#C.Cl
CAS DataBase Reference
14611-52-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-36
RIDADR 
3249
WGK Germany 
3
RTECS 
DA0292500
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2921490002
Hazardous Substances Data
14611-52-0(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): 81 i.v., 280 s.c. (Magyar)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3134
Product name
Selegiline Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$272.65
Updated
2025/07/31
Sigma-Aldrich
Product number
M003
Product name
R-(?)-Deprenyl hydrochloride
Purity
powder, ≥98% (HPLC)
Packaging
1g
Price
$304
Updated
2025/07/31
Sigma-Aldrich
Product number
BP705
Product name
Selegiline hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100 mg
Price
$274
Updated
2025/07/31
Sigma-Aldrich
Product number
1611900
Product name
Selegiline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$425
Updated
2025/07/31
Cayman Chemical
Product number
15046
Product name
R-(-)-Deprenyl (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$32
Updated
2024/03/01
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Selegiline hydrochloride Chemical Properties,Usage,Production

Description

Deprenyl (14611-52-0) is a potent inhibitor of monoamine oxidase B (MAO- B) which has been used for the treatment of Parkinson’s disease.1,2 Displays neuroprotective effects rescuing nigral dopaminergic neurons after systemic MPTP treatment.3 Rescues PC12 cells from trophic withdrawal-induced apoptosis.4 Glyceraldehyde-3-phosphate dehydrogenase has been found to be the putative target responsible for its neuroprotective effects.5

Chemical Properties

Crystalline Solid

Uses

antibacterial

Uses

Antidepressant, Antiparkinsonian

Uses

Selegiline hydrochloride is used to alleviate the symptonms of Parkinsons disease

brand name

Eldepryl (Somerset); Zelapar (Valeant).

Biological Activity

Selective inhibitor of monoamine oxidase B (MAO-B).

Clinical Use

Monoamine-oxidase-B inhibitor:
Treatment of Parkinson’s disease

Veterinary Drugs and Treatments

Selegiline is approved for use in dogs for the treatment of Cushing’s disease and for Canine Cognitive Dysfunction (so-called “old dog dementia”). Its use for Cushing’s disease is somewhat controversial as clinical studies evaluating its efficacy have shown disappointing results. In humans, selegiline’s primary indication is for the adjunctive treatment of Parkinson’s disease.

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: hyperpyrexia and CNS toxicity reported with pethidine - avoid; avoid with opioid analgesics.
Antidepressants: avoid with citalopram and escitalopram; increased risk of hypertension and CNS excitation with fluvoxamine, sertraline or venlafaxine, do not start selegiline until 1 week after stopping them, avoid for 2 weeks after stopping selegiline; increased risk of hypertension and CNS excitation with paroxetine, do not start selegiline until 2 weeks after stopping paroxetine, avoid for 2 weeks after stopping selegiline avoid concomitant use with other MAOIs and moclobemide (can lead to hypertensive crisis) - allow at least 14 days before starting a MAOI; avoid concomitant use with fluoxetine, allow 5 weeks between stopping fluoxetine and starting selegiline; allow 14 days between stopping selegiline and starting fluoxetine; increased CNS toxicity with tricyclics and vortioxetine.
Oestrogens and progestogens: concentration of selegiline increased - avoid.
Sympathomimetics: concomitant use is not recommended; risk of hypertensive crisis with dopamine.

Metabolism

Extensive first-pass metabolism in the liver to produce at least 5 metabolites, including desmethylselegiline (norselegiline), N-methylamfetamine, and amfetamine. Plasma concentrations of selegiline metabolites are greatly reduced after doses of the oral lyophilisate preparation, the majority of which undergoes absorption through the buccal mucosa.
Selegiline is excreted as metabolites mainly in the urine and about 15% appears in the faeces.

References

[1] MANFRED GERLACH  Moussa B H Y  Peter Riederer. The molecular pharmacology of L-deprenyl[J]. European Journal of Pharmacology: Molecular Pharmacology, 1992, 226 2: Pages 97-108. DOI:10.1016/0922-4106(92)90170-z
[2] JAMES W. TETRUD  J. W L. The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson”s Disease[J]. Science, 1989, 245 4917. DOI:10.1126/science.2502843
[3] DR. W. G. TATTON  C. E G. Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism[J]. Journal of Neuroscience Research, 1991, 30 4: 666-672. DOI:10.1002/jnr.490300410
[4] W. G. TATTON. (−)-Deprenyl Reduces PC12 Cell Apoptosis by Inducing New Protein Synthesis[J]. Journal of Neurochemistry, 1994, 63 4: 1572-1575. DOI:10.1046/j.1471-4159.1994.63041572.x
[5] E KRAGTEN. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl.[J]. The Journal of Biological Chemistry, 1998, 273 10: 5821-5828. DOI:10.1074/jbc.273.10.5821

Selegiline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Selegiline hydrochloride manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Selegiline hydrochloride 14611-52-0
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-06-06
Hebei Yanxi Chemical Co., Ltd.
Product
selegiline hydrochloride 14611-52-0
Price
US $50.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
100000
Release date
2023-09-06
Hebei Dangtong Import and export Co LTD
Product
Selegiline hydrochloride 14611-52-0
Price
US $4000.00-3200.00/Grams
Min. Order
100Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06

14611-52-0, Selegiline hydrochlorideRelated Search:

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