doxorubicin(6-maleimidocaproyl)hydrazone

Product Name: doxorubicin(6-maleimidocaproyl)hydrazone
CAS No.: 151038-96-9
Chemical Name: doxorubicin(6-maleimidocaproyl)hydrazone
Synonyms: DOXO-EMCH;INNO-206;MC-DOXHZN;Aldoxorubici;Doxorubicin-EMCH;MC DOXHZN,MCDOXHZN;INNO-206 (Aldoxorubicin);Doxorubicin-hydrazone-caproyl-maleimide;doxorubicin(6-maleimidocaproyl)hydrazone;DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN
CBNumber: CB51374839
Molecular Formula: C37H42N4O13
Formula Weight: 750.74838
MOL File: 151038-96-9.mol

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doxorubicin(6-maleimidocaproyl)hydrazone Property

Density: 1.60
solubility: Soluble in DMSO
pka: 7.38±0.60(Predicted)

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Safety

Safety Statements: 23-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 2mg
Price: $113
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 5mg
Price: $188
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 10mg
Price: $255
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005221
Product name: INNO-206
Purity: 95.00%
Packaging: 5MG
Price: $922.3
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 50mg
Price: $960
Updated: 2021/12/16

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doxorubicin(6-maleimidocaproyl)hydrazone Chemical Properties,Usage,Production

Uses

Doxorubicin-hydrazone-caproyl-maleimide is an albumin-binding prodrug of doxorubicin and a promising clinical candidate for the treatment of a broad range of solid tumors

Biological Activity

the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (inno-206), formerly known as doxo-emch, is a prodrug of the anticancer agent doxorubicin which selectively binds to the cys34 of circulating albumin and accumulates in solid tumors due to passive targeting[1]. inno-206 shows significantly superior antitumor efficacy over free doxorubicin in a spectrum of preclinical tumor models [2].

in vivo

in a murine renal cell carcinoma model and in breast carcinoma xenograft models, inno-206 has shown superior activity over doxorubicin. inno-206 has shown more potent antitumor efficacy than free doxorubicin in the tumor models and is thus a promising clinical candidate for treating a broad range of solid tumors [2].

References

[1]. kratz f. doxo-emch (inno-206): the first albumin-binding prodrug of doxorubicin to enter

doxorubicin(6-maleimidocaproyl)hydrazone Preparation Products And Raw materials

Raw materials

Preparation Products

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doxorubicin(6-maleimidocaproyl)hydrazone Suppliers

China 43 South Korea 1 United Kingdom 1 United States 9 Global 54

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
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Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
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Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
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Chengdu Dianchun Technology Co., Ltd

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Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
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ShangHai Biochempartner Co.,Ltd

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Amadis Chemical Company Limited

Tel: 571-89925085
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ProdList: 131957
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
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Lynnchem

Tel: 86-(0)29-85992781 17792393971
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View Lastest Price from doxorubicin(6-maleimidocaproyl)hydrazone manufacturers

Career Henan Chemical Co

Product: DOXO-EMCH 151038-96-9
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

Career Henan Chemical Co

Product: doxorubicin(6-maleimidocaproyl)hydrazone 151038-96-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

151038-96-9, doxorubicin(6-maleimidocaproyl)hydrazoneRelated Search:

doxorubicin(6-maleimidocaproyl)hydrazone

(E)-N'-(1-((2R,4R)-4-((2S,4R,5R,6R)-4-aMino-5-hydroxy-6-Methyltetrahydro-2H-pyran-2-yloxy)-2,5,12-trihydroxy-7-Methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide

INNO-206

INNO-206 (Aldoxorubicin)

DOXO-EMCH

Doxorubicin-EMCH

N'-[(1E)-1-{4-[(3-Amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexane hydrazide

MC-DOXHZN

DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN

1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide

Doxorubicin-hydrazone-caproyl-maleimide

1H-Pyrrole-1-hexanoicacid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide

Aldoxorubici

MC DOXHZN,MCDOXHZN

N'-{1-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-hydroxyethylidene}-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide

151038-96-9

C37H42N4O13