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BMS-502

Product Name
BMS-502
CAS No.
2407854-18-4
Chemical Name
BMS-502
Synonyms
BMS-502;BMS-502 (Compound 22);BMS-502（SCHEMBL21830991）;8-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile
CBNumber
CB513765779
Formula Weight
0
MOL File
2407854-18-4.mol
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BMS-502 Property

solubility 
DMF: 10 mg/ml
DMSO: 1 mg/ml
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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BMS-502 Chemical Properties,Usage,Production

Uses

BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1].

Definition

BMS-502 is a dual DGKα and ζ inhibitor. BMS-502 demonstrated dose-dependent immune stimulation in the mouse OT-1 model, setting the stage for a drug discovery program. BMS-502 demonstrated substantial inhibitory activity against DGKs α, ζ and ι[1].

in vivo

BMS-502 (Compound 22) (0-10mg/kg; PO; 24h) demonstrates dose-dependent immune stimulation in the mouse OT-1 model[1].
Pharmacokinetic Analysis in C57 black mice Model[1]

RouteDose (mg/kg)AUClast (μMh)t1/2 (h)Tmax (h)Cmax (μM)Cl (m/min/kg)Vss (mL/kg)F (%)
i.v.114.822.5//1.93.9/
p.o.548/3.01.08//65
Animal Model:OT-1 mouse model[1]
Dosage:0-10 mg/kg
Administration:Oral administration; 24 h
Result:Caused no significant increase in activated effector T-cells.

References

[1] Louis Chupak* and Susan Wee. “Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.” ACS Medicinal Chemistry Letters 14 7 (2023): 929–935.

BMS-502 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-502 Suppliers

China 28 United States 2 Global 30
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Henan Alpha Chemical Co., Ltd.
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0371-55055611 18137792234
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3957071458@qq.com
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Guangzhou Younan Technology Co., Ltd
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020-82000279 18988941452
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YN_research@163.com
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China
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
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15317229551
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QQ:3607245178
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15151849396@163.com
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China
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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3525679403@qq.com
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China
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View Lastest Price from BMS-502 manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
BMS-502 2407854-18-4
Price
US $0.00-0.00/MG
Min. Order
1MG
Purity
98
Supply Ability
100G
Release date
2024-04-17

2407854-18-4, BMS-502Related Search:


  • BMS-502
  • BMS-502 (Compound 22)
  • BMS-502（SCHEMBL21830991）
  • 8-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile
  • 2407854-18-4
  • BMS-502 (COMPOU