ChemicalBook > CAS DataBase List > FPL 62064

FPL 62064

Product Name
FPL 62064
CAS No.
103141-09-9
Chemical Name
FPL 62064
Synonyms
FPL 62064;FPL 62064, 10 mM in DMSO;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
CBNumber
CB51384847
Molecular Formula
C16H15N3O
Formula Weight
265.31
MOL File
103141-09-9.mol
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FPL 62064 Property

Boiling point:
442.6±25.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: 250 mg/mL (942.29 mM)
pka
2.42±0.50(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M350460
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M350460
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
100mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
3655AL
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
100mg
Price
$298
Updated
2021/12/16
AK Scientific
Product number
3655AL
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
10mg
Price
$149
Updated
2021/12/16
ChemScene
Product number
CS-0024722
Product name
FPL62064
Purity
98.46%
Packaging
5mg
Price
$350
Updated
2021/12/16
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FPL 62064 Chemical Properties,Usage,Production

Uses

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].

in vivo

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].

Animal Model:Female LACA mice (20-30 g) injected with immune complex[1].
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection
Result:Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation.

References

[1] Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DOI:10.1007/BF01966309
[2] Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. DOI:10.1002/ardp.201900308

FPL 62064 Preparation Products And Raw materials

Raw materials

Preparation Products

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FPL 62064 Suppliers

China 36 India 1 United States 6 Global 43
Hotechem Shanghai Co., Ltd.,
Tel
021-34621078 13120882795
Fax
021-34622517
Email
465106944@qq.com
Country
China
ProdList
857
Advantage
56
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
6344
Advantage
55
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
15706
Advantage
58
Jiangsu aikang biomedical research and development co., LTD
Tel
025-66110311 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15526
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32222
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Shanghai TenSus Biotechnology Co., Ltd.
Tel
021-50895067 18616507272
Fax
021-50895067
Email
tensus@163.com
Country
China
ProdList
7535
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58

103141-09-9, FPL 62064Related Search:

FORMANILIDE Acetanilide

  • 1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-
  • FPL 62064
  • N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
  • Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
  • FPL 62064, 10 mM in DMSO
  • 103141-09-9