BMS453

Product Name: BMS453
CAS No.: 166977-43-1
Chemical Name: BMS453
Synonyms: BMS453;BMS453, 10 mM in DMSO;BMS-189453 (BMS189453;(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid;(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid;4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid;Benzoic acid, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-;Inhibitor,BMS453,retinoid,RAR/RXR,inhibit,BMS-453,BMS 189453,TGFβ,breast,RARβ,RARγ,Retinoid X receptors,BMS189453,arrest,cell,RARα,Retinoic acid receptors
CBNumber: CB51387459
Molecular Formula: C27H24O2
Formula Weight: 380.48
MOL File: 166977-43-1.mol

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BMS453 Property

Boiling point:: 560.9±50.0 °C(Predicted)
Density: 1.167±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 4.27±0.10(Predicted)
color: white to beige
InChI: 1S/C27H24O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-16,18H,17H2,1-2H3,(H,28,29)/b9-8+
InChIKey: VUODRPPTYLBGFM-CMDGGOBGSA-N
SMILES: OC(C(C=C1)=CC=C1/C=C/C(C=C2)=CC3=C2C(C)(C)CC=C3C4=CC=CC=C4)=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1149
Product name: BMS-189453
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1149
Product name: BMS-189453
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $550
Updated: 2025/07/31

Cayman Chemical

Product number: 19076
Product name: BMS 453
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19076
Product name: BMS 453
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19076
Product name: BMS 453
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

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BMS453 Chemical Properties,Usage,Production

Uses

BMS 453 is a synthetic retinoid and RARβ antagonist which also displays antagonist acitivity in RARα.

Definition

ChEBI: BMS-453 is a member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor gamma (RARbeta) agonist that acts as an antagonist against RARalpha and RARgamma. It has a role as a retinoic acid receptor beta agonist, a retinoic acid receptor gamma antagonist, a retinoic acid receptor alpha antagonist and a teratogenic agent. It is a member of dihydronaphthalenes, a member of benzoic acids and a stilbenoid.

Biological Activity

BMS-189453 is a potent RARβ agonist th at acts as an antagonist against RARα and RARγ. BMS-189453 induces RARβ reporter gene expression at sub nanomolar levels, and is 30 fold more potent than all-trans retinoic acid for inducing TGFβ activity in normal breast cells. The compound BMS-189453 does not transactivate RARα or γ transcriptional activity, but binding to those family members induces a strong transrepression of phorbol ester-induced AP-1 activity (IC50 = 0.1 nM in HeLa and MCSF-7). BMS-189453 significantly increases the efficiency of cardiac differentiation of hESCs.', 'BMS-189453 specifically has sufficient bioavailability in rats and monkeys. BMS-189453 only binds to α, β, and γ retinoid receptors but its activation is unknown. BMS-189453 is found to inhibit the action of collagenase-3 (MMP-13) which catalyses cartilage matrix degradation. Thus, it serves to tre at rheumatoid arthritis.

BMS453 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS453 Suppliers

China 76 United Kingdom 2 United States 10 Global 88

3B Pharmachem (Wuhan) International Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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166977-43-1, BMS453Related Search:

BMS453

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid

(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid

BMS-189453 (BMS189453

(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid

Benzoic acid, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-

Inhibitor,BMS453,retinoid,RAR/RXR,inhibit,BMS-453,BMS 189453,TGFβ,breast,RARβ,RARγ,Retinoid X receptors,BMS189453,arrest,cell,RARα,Retinoic acid receptors

BMS453, 10 mM in DMSO

166977-43-1