BMS453
- Product Name
- BMS453
- CAS No.
- 166977-43-1
- Chemical Name
- BMS453
- Synonyms
- BMS453;BMS453, 10 mM in DMSO;BMS-189453 (BMS189453;(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid;(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid;4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid;Benzoic acid, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-;Inhibitor,BMS453,retinoid,RAR/RXR,inhibit,BMS-453,BMS 189453,TGFβ,breast,RARβ,RARγ,Retinoid X receptors,BMS189453,arrest,cell,RARα,Retinoic acid receptors
- CBNumber
- CB51387459
- Molecular Formula
- C27H24O2
- Formula Weight
- 380.48
- MOL File
- 166977-43-1.mol
BMS453 Property
- Boiling point:
- 560.9±50.0 °C(Predicted)
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 4.27±0.10(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1149
- Product name
- BMS-189453
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- SML1149
- Product name
- BMS-189453
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- 19076
- Product name
- BMS 453
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19076
- Product name
- BMS 453
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 19076
- Product name
- BMS 453
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
BMS453 Chemical Properties,Usage,Production
Uses
BMS 453 is a synthetic retinoid and RARβ antagonist which also displays antagonist acitivity in RARα.
Definition
ChEBI: BMS-453 is a member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor gamma (RARbeta) agonist that acts as an antagonist against RARalpha and RARgamma. It has a role as a retinoic acid receptor beta agonist, a retinoic acid receptor gamma antagonist, a retinoic acid receptor alpha antagonist and a teratogenic agent. It is a member of dihydronaphthalenes, a member of benzoic acids and a stilbenoid.
Biological Activity
BMS-189453 is a potent RARβ agonist th at acts as an antagonist against RARα and RARγ. BMS-189453 induces RARβ reporter gene expression at sub nanomolar levels, and is 30 fold more potent than all-trans retinoic acid for inducing TGFβ activity in normal breast cells. The compound BMS-189453 does not transactivate RARα or γ transcriptional activity, but binding to those family members induces a strong transrepression of phorbol ester-induced AP-1 activity (IC50 = 0.1 nM in HeLa and MCSF-7). BMS-189453 significantly increases the efficiency of cardiac differentiation of hESCs.', 'BMS-189453 specifically has sufficient bioavailability in rats and monkeys. BMS-189453 only binds to α, β, and γ retinoid receptors but its activation is unknown. BMS-189453 is found to inhibit the action of collagenase-3 (MMP-13) which catalyses cartilage matrix degradation. Thus, it serves to tre at rheumatoid arthritis.
BMS453 Preparation Products And Raw materials
Raw materials
Preparation Products
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