ChemicalBook > CAS DataBase List > 1,4,7-triazacyclononane-N,N',N''-triacetic acid

1,4,7-triazacyclononane-N,N',N''-triacetic acid

Product Name
1,4,7-triazacyclononane-N,N',N''-triacetic acid
CAS No.
56491-86-2
Chemical Name
1,4,7-triazacyclononane-N,N',N''-triacetic acid
Synonyms
NOTA;2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic acid;NOTA(M-600);1,4,7-triazacyclononane-N,N',N''-triacetic acid;1,4,7-triazacyclononane-1,4,7-triacetic acid/NOTA;Octahydro-1H-1,4,7-triazonine-1,4,7-triacetic Acid;1H-1,4,7-Triazonine-1,4,7-triaceticacid, hexahydro-;1,4,7-triazacyclononane-N,N',N''-triacetic acid(NOTA);2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid;2,2',2''-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid
CBNumber
CB51387909
Molecular Formula
C12H21N3O6
Formula Weight
303.31
MOL File
56491-86-2.mol
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1,4,7-triazacyclononane-N,N',N''-triacetic acid Property

Boiling point:
572.9±50.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
-20°C, protect from light
form 
Solid
pka
1.82±0.10(Predicted)
color 
White to off-white
Water Solubility 
Water : 125 mg/mL (412.12 mM; Need ultrasonic)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3910
Product name
2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic Acid
Packaging
200MG
Price
$230
Updated
2025/07/31
TCI Chemical
Product number
T3910
Product name
2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic Acid
Packaging
1G
Price
$694
Updated
2025/07/31
chempep
Product number
331402
Product name
NOTA
Packaging
5g
Price
$1700
Updated
2021/12/16
chempep
Product number
331402
Product name
NOTA
Packaging
500mg
Price
$428
Updated
2021/12/16
chempep
Product number
331402
Product name
NOTA
Packaging
1g
Price
$676
Updated
2021/12/16
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1,4,7-triazacyclononane-N,N',N''-triacetic acid Chemical Properties,Usage,Production

Description

NOTA is a bifunctional chelating agent that shows high complexation constant with metals, such as gallium.

Uses

NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6].

in vivo

NOTA participates in the synthesis of [64Cu]NOTA-pentixather to enables high resolution PET imaging of CXCR4 expressionin in Daudi lymphoma-bearing severe combined immunodeficiency (SCID) mice [3].
NOTA participates in the synthesis of 68Ga-NOTA-RGD for MicroPET/CT imaging of αvβ3integrin in rat myocardial infarction[4].
NOTA participates in the synthesis of [68Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma[5].
NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice[6].

IC 50

RDC Bifunctional Chelator

References

[1] Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. DOI:10.1021/bc200227d
[2] Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. DOI:10.1016/j.ultras.2012.06.014
[3] Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2(1):2. DOI:10.1186/s41181-016-0020-6
[4] Menichetti L, et al. MicroPET/CT imaging of αvβ? integrin via a novel ??Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1265-74. DOI:10.1007/s00259-013-2432-9
[5] Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2749-2760. DOI:10.1007/s00259-021-05218-1
[6] Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6(12):e28005. DOI:10.1371/journal.pone.0028005

1,4,7-triazacyclononane-N,N',N''-triacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4,7-triazacyclononane-N,N',N''-triacetic acid Suppliers

China 73 Japan 1 United States 3 Global 77
TOKYO CHEMICAL INDUSTRY CO., LTD.
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Bide Pharmatech Ltd.
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View Lastest Price from 1,4,7-triazacyclononane-N,N',N''-triacetic acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
NOTA 56491-86-2
Price
US $0.00/mg
Min. Order
250mg
Purity
>95.00%
Supply Ability
250mg
Release date
2024-04-01
Honest Joy Holdings Limited
Product
1,4,7-triazacyclononane-N,N',N''-triacetic acid 56491-86-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
1,4,7-triazacyclononane-N,N',N''-triacetic acid 56491-86-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200g
Release date
2020-02-01

56491-86-2, 1,4,7-triazacyclononane-N,N',N''-triacetic acidRelated Search:

N-ACETYLLACTOSAMINE 1,4,7-Triazacyclononane CHX-A''-DTPA(B-355) DTPA-tetra (t-Bu ester)(B-365) p-NH2-Bn-NOTA(B-601) (p-SCN-Bn)-NOTA

  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid
  • NOTA(M-600)
  • 2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic acid
  • 2,2',2''-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid
  • 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
  • NOTA
  • 1H-1,4,7-Triazonine-1,4,7-triaceticacid, hexahydro-
  • 1H-1,4,7-Triazonine-1,4,7-triacetic acid, hexahydro-56491-86-2
  • 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid NOTA
  • 1, 4, 8, 11-Tetraazabicyclo[6.6. 2]hexadecane-4, 11-diacetic acid
  • Octahydro-1H-1,4,7-triazonine-1,4,7-triacetic Acid
  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid(NOTA)
  • 1,4,7-triazacyclononane-1,4,7-triacetic acid/NOTA
  • 56491-86-2