ChemicalBook > CAS DataBase List > 1,4,7-Triazacyclononane

1,4,7-Triazacyclononane

Product Name
1,4,7-Triazacyclononane
CAS No.
4730-54-5
Chemical Name
1,4,7-Triazacyclononane
Synonyms
TACN;157715;1,4,7-triazonane;Triazacyclononane;TRIETHYLENETRIAMINE;1,4,7-Triazacyclonomane;1,4,7-TRIAZACYCLONONANE;1,4,8-Triazacyclononane;Triazacyclononanewhitextl;1,4,7-Triazacyclononane hcl
CBNumber
CB4234922
Molecular Formula
C6H15N3
Formula Weight
129.2
MOL File
4730-54-5.mol
More
Less

1,4,7-Triazacyclononane Property

Melting point:
42-45 °C (lit.)
Boiling point:
110-130 °C/7 mmHg (lit.)
Density 
0.9987 (rough estimate)
refractive index 
1.4620 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
Water Solubility 
Soluble in water
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
crystal
pka
10.57±0.20(Predicted)
color 
white
BRN 
773877
InChIKey
ITWBWJFEJCHKSN-UHFFFAOYSA-N
More
Less

Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3259 8/PG 2
WGK Germany 
3
F 
3-10-34
HazardClass 
8
PackingGroup 
III
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
311308
Product name
1,4,7-Triazacyclononane
Purity
95%
Packaging
100mg
Price
$49.6
Updated
2024/03/01
Sigma-Aldrich
Product number
311308
Product name
1,4,7-Triazacyclononane
Purity
95%
Packaging
500mg
Price
$151.2
Updated
2024/03/01
TCI Chemical
Product number
T1878
Product name
1,4,7-Triazacyclononane
Purity
>98.0%(GC)
Packaging
200mg
Price
$60
Updated
2024/03/01
TCI Chemical
Product number
T1878
Product name
1,4,7-Triazacyclononane
Purity
>98.0%(GC)
Packaging
1g
Price
$172
Updated
2024/03/01
Strem Chemicals
Product number
07-2500
Product name
1,4,7-Triazacyclononane, 97%
Packaging
25mg
Price
$33
Updated
2024/03/01
More
Less

1,4,7-Triazacyclononane Chemical Properties,Usage,Production

Description

1,4,7-Triazacyclononane, known as "TACN" which is pronounced "tack-en," is a cyclic organic compound with the formula C6H12(NH)3. TACN is derived, formally speaking, from cyclononane by replacing three equidistant CH2 groups with NH groups. TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include diazacyclohexane, C4H8(NH)2, and the cyclic tetramer 1,4,7,10-tetraazacyclododecane.

Chemical Properties

White - light yellow solid

Uses

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.

Uses

1,4,7-Triazacyclononane (TACN) is a versatile platform from which various ligands can be derived to form effective chelators for (radio)copper(II) complexation. The ability of TACN-derivatives to form highly stable complexes with copper(II) is greatly influenced by the number and type of substituents on the macrocyclic ring. The formed copper(II) complexes show a broad variability in their thermodynamic stability and kinetic inertness, varying in structure from square-pyramidal to distorted octahedral. TACN-based BFCAs have also been used for indirect radiolabelling of biomolecules, rendering them suitable for imaging and therapy.

Application

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Possible reagent for compleximetric titrations with high cation-binding selectivity.

Preparation

The ligand is prepared from diethylene triamine as follows by macrocyclization using ethyleneglycol ditosylate.
H2NCH2CH2NHCH2CH2NH2 + 3 TsCl → Ts(H)NCH2CH2N(Ts)CH2CHH2N(H)Ts + 3 HCl Ts(H)NCH2CH2N(Ts)CH2CH2N(H)Ts + 2 NaOEt → Ts(Na)NCH2CH2N(Ts)CH2CH2N(Na)Ts Ts(Na)NCHH2CH2N(Ts)CH2CH2N(Na)Ts + TsOCH2CH2OTs + → [(CH2CH2N(Ts)]3 + 2 NaOTs [(CH2CH2N(Ts)]3 + 3 H2O → [CH2CH2NH]3 + 3 HOTs

Definition

ChEBI: 1,4,7-triazonane is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.

1,4,7-Triazacyclononane Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,4,7-Triazacyclononane Suppliers

China 176 Germany 4 India 5 Japan 1 South Korea 1 Switzerland 1 United Kingdom 6 United States 23 Global 217
Tianjin YongSheng Biotechnology Co., Ltd.
Tel
022-60987737 13512258274
Fax
86-022-23500597
Email
sales@immortalbio.com
Country
China
ProdList
154
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
Jiangxi Boye Medical Technology Co., Ltd
Tel
027-18971341812/18971341812 18971341812
Fax
027-81625225
Email
anikay@boyechemicals.com
Country
China
ProdList
659
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
More
Less

View Lastest Price from 1,4,7-Triazacyclononane manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $1.00-1.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-12
Xian confluore Biological Technology Co., Ltd.
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $0.00/g
Min. Order
10g
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-08

4730-54-5, 1,4,7-TriazacyclononaneRelated Search:

N-NONANE 1,4-Dioxane 1,4,7-TRIMETHYL-1,4,7-TRIAZACYCLONONANE 1,4,7-Triazacyclononane trihydrochloride CYCLEN-GLYOXAL (p-SCN-Bn)-NOTA HEXABENZILISOVYURTSITAN bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate) monohydrate 1,4,7-triazacyclononane-N,N',N''-triacetic acid 1,4,7-Triazacyclononane 1,4,7-Triazacyclononane-1,4,7-triacetic acid,1,4,7-Triazacyclononane-1,4,7-trisacetic acid N,N',N''-tris(2-methyl-(2-mercaptopropyl))-1,4,7-triazacyclononane-pertechnetate N',N',N'-tris(2-methyl-2-mercaptopropyl)-1,4,7-triazacyclononane N,N,N',N',N'',N''-Hexamethyl-1,4,7-triazacyclononane-1,4,7-tripropionamide N,N,N',N',N'',N''-Hexamethyl-1,4,7-triazacyclononane-1,4,7-tri(acetamide) 1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonate monoethyl ester) 3-Benzyl-6,9-dimethyl-3,6,9-triazacyclononane,1-Benzyl-4,7-dimethyl-1,4,7-triazacyclononane,1,4-Dimethyl-7-benzyl-1,4,7-triazacyclononane 1,7-Dimethyl-4-[2-(ethylamino)ethyl]-1,4,7-triazacyclononane

  • 1,4,7-TRIAZACYCLONONANE
  • OCTAHYDRO-1H-1,4,7-TRIAZONINE
  • Octahydro-1H-1,4,7-triazonine, Triethylenetriamine
  • 1,4,7-Triazacyclonomane
  • TRIETHYLENETRIAMINE
  • Triazacyclononanewhitextl
  • 1,4,7-Triazacyclononane,97%
  • 1,4,7-triazonane
  • DOTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr
  • 157715
  • 1,4,7-Triazacyclononane hcl
  • 1,4,7-triazonane trihydrochloride
  • TACN
  • 1,4,8-Triazacyclononane
  • 1H-1,4,7-Triazonine, octahydro-
  • Triazacyclononane
  • 1,4,7-triazacyclononane (TACN)
  • 4730-54-5
  • 4370-54-5
  • Synthetic Reagents
  • Crown Ethers
  • Chelation/Complexation Compounds
  • Achiral Nitrogen
  • Cy-N
  • organic amine