ChemicalBook > CAS DataBase List > 1,4,7-Triazacyclononane

1,4,7-Triazacyclononane

Product Name
1,4,7-Triazacyclononane
CAS No.
4730-54-5
Chemical Name
1,4,7-Triazacyclononane
Synonyms
TACN;157715;1,4,7-triazonane;Triazacyclononane;TRIETHYLENETRIAMINE;1,4,7-Triazacyclonomane;1,4,7-TRIAZACYCLONONANE;1,4,8-Triazacyclononane;Triazacyclononanewhitextl;1,4,7-Triazacyclononane hcl
CBNumber
CB4234922
Molecular Formula
C6H15N3
Formula Weight
129.2
MOL File
4730-54-5.mol
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1,4,7-Triazacyclononane Property

Melting point:
42-45 °C (lit.)
Boiling point:
110-130 °C/7 mmHg (lit.)
Density 
0.9987 (rough estimate)
refractive index 
1.4620 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
Water Solubility 
Soluble in water
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
crystal
pka
10.57±0.20(Predicted)
color 
white
BRN 
773877
InChIKey
ITWBWJFEJCHKSN-UHFFFAOYSA-N
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3259 8/PG 2
WGK Germany 
3
F 
3-10-34
HazardClass 
8
PackingGroup 
III
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
311308
Product name
1,4,7-Triazacyclononane
Purity
95%
Packaging
100mg
Price
$49.6
Updated
2024/03/01
Sigma-Aldrich
Product number
311308
Product name
1,4,7-Triazacyclononane
Purity
95%
Packaging
500mg
Price
$151.2
Updated
2024/03/01
TCI Chemical
Product number
T1878
Product name
1,4,7-Triazacyclononane
Purity
>98.0%(GC)
Packaging
200mg
Price
$60
Updated
2024/03/01
TCI Chemical
Product number
T1878
Product name
1,4,7-Triazacyclononane
Purity
>98.0%(GC)
Packaging
1g
Price
$172
Updated
2024/03/01
Strem Chemicals
Product number
07-2500
Product name
1,4,7-Triazacyclononane, 97%
Packaging
25mg
Price
$33
Updated
2024/03/01
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1,4,7-Triazacyclononane Chemical Properties,Usage,Production

Description

1,4,7-Triazacyclononane, known as "TACN" which is pronounced "tack-en," is a cyclic organic compound with the formula C6H12(NH)3. TACN is derived, formally speaking, from cyclononane by replacing three equidistant CH2 groups with NH groups. TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include diazacyclohexane, C4H8(NH)2, and the cyclic tetramer 1,4,7,10-tetraazacyclododecane.

Chemical Properties

White - light yellow solid

Uses

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.

Uses

1,4,7-Triazacyclononane (TACN) is a versatile platform from which various ligands can be derived to form effective chelators for (radio)copper(II) complexation. The ability of TACN-derivatives to form highly stable complexes with copper(II) is greatly influenced by the number and type of substituents on the macrocyclic ring. The formed copper(II) complexes show a broad variability in their thermodynamic stability and kinetic inertness, varying in structure from square-pyramidal to distorted octahedral. TACN-based BFCAs have also been used for indirect radiolabelling of biomolecules, rendering them suitable for imaging and therapy.

Application

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Possible reagent for compleximetric titrations with high cation-binding selectivity.

Preparation

The ligand is prepared from diethylene triamine as follows by macrocyclization using ethyleneglycol ditosylate.
H2NCH2CH2NHCH2CH2NH2 + 3 TsCl → Ts(H)NCH2CH2N(Ts)CH2CHH2N(H)Ts + 3 HCl Ts(H)NCH2CH2N(Ts)CH2CH2N(H)Ts + 2 NaOEt → Ts(Na)NCH2CH2N(Ts)CH2CH2N(Na)Ts Ts(Na)NCHH2CH2N(Ts)CH2CH2N(Na)Ts + TsOCH2CH2OTs + → [(CH2CH2N(Ts)]3 + 2 NaOTs [(CH2CH2N(Ts)]3 + 3 H2O → [CH2CH2NH]3 + 3 HOTs

Definition

ChEBI: 1,4,7-triazonane is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.

1,4,7-Triazacyclononane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4,7-Triazacyclononane Suppliers

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View Lastest Price from 1,4,7-Triazacyclononane manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $1.00-1.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-12
Xian confluore Biological Technology Co., Ltd.
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $0.00/g
Min. Order
10g
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
1,4,7-Triazacyclononane 4730-54-5
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-08

4730-54-5, 1,4,7-TriazacyclononaneRelated Search:

N-NONANE 1,4-Dioxane 1,4,7-TRIMETHYL-1,4,7-TRIAZACYCLONONANE 1,4,7-Triazacyclononane trihydrochloride CYCLEN-GLYOXAL (p-SCN-Bn)-NOTA HEXABENZILISOVYURTSITAN bis(N,N',N''-trimethyl-1,4,7-triazacyclononane)-trioxo-dimanganese (IV) di(hexafluorophosphate) monohydrate 1,4,7-triazacyclononane-N,N',N''-triacetic acid 1,4,7-Triazacyclononane 1,4,7-Triazacyclononane-1,4,7-triacetic acid,1,4,7-Triazacyclononane-1,4,7-trisacetic acid N,N',N''-tris(2-methyl-(2-mercaptopropyl))-1,4,7-triazacyclononane-pertechnetate N',N',N'-tris(2-methyl-2-mercaptopropyl)-1,4,7-triazacyclononane N,N,N',N',N'',N''-Hexamethyl-1,4,7-triazacyclononane-1,4,7-tripropionamide N,N,N',N',N'',N''-Hexamethyl-1,4,7-triazacyclononane-1,4,7-tri(acetamide) 1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonate monoethyl ester) 3-Benzyl-6,9-dimethyl-3,6,9-triazacyclononane,1-Benzyl-4,7-dimethyl-1,4,7-triazacyclononane,1,4-Dimethyl-7-benzyl-1,4,7-triazacyclononane 1,7-Dimethyl-4-[2-(ethylamino)ethyl]-1,4,7-triazacyclononane

  • 1,4,7-TRIAZACYCLONONANE
  • OCTAHYDRO-1H-1,4,7-TRIAZONINE
  • Octahydro-1H-1,4,7-triazonine, Triethylenetriamine
  • 1,4,7-Triazacyclonomane
  • TRIETHYLENETRIAMINE
  • Triazacyclononanewhitextl
  • 1,4,7-Triazacyclononane,97%
  • 1,4,7-triazonane
  • DOTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr
  • 157715
  • 1,4,7-Triazacyclononane hcl
  • 1,4,7-triazonane trihydrochloride
  • TACN
  • 1,4,8-Triazacyclononane
  • 1H-1,4,7-Triazonine, octahydro-
  • Triazacyclononane
  • 1,4,7-triazacyclononane (TACN)
  • 4730-54-5
  • 4370-54-5
  • Synthetic Reagents
  • Crown Ethers
  • Chelation/Complexation Compounds
  • Achiral Nitrogen
  • Cy-N
  • organic amine