tarazepide
- Product Name
- tarazepide
- CAS No.
- 141374-81-4
- Chemical Name
- tarazepide
- Synonyms
- tarazepide;4H-Pyrrolo[3,2,1-ij]quinoline-2-carboxamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-5,6-dihydro-
- CBNumber
- CB51393722
- Molecular Formula
- C28H24N4O2
- Formula Weight
- 448.524
- MOL File
- 141374-81-4.mol
tarazepide Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- API0009200
- Product name
- TARAZEPIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.66
- Updated
- 2021/12/16
tarazepide Chemical Properties,Usage,Production
Uses
Tarazepide is a potent and specific CCK-A receptor antagonist.
Definition
ChEBI: Tarazepide is a N-acyl-amino acid.
in vivo
Tarazepide decreases duodenal electric activity, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with Tarazepide[2].
References
[1] Zabielski R, et al. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept. 1998 Nov 30;78(1-3):113-23. DOI:10.1016/s0167-0115(98)00139-6
[2] Nawrot-Porabka K, et al. Leptin is able to stimulate pancreatic enzyme secretion via activation of duodeno-pancreatic reflex and CCK release. J Physiol Pharmacol. 2004 Jul;55 Suppl 2:47-57. PMID:15608360
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Raw materials
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