Bimosiamose

Product Name: Bimosiamose
CAS No.: 187269-40-5
Chemical Name: Bimosiamose
Synonyms: TBC-1269;Bimosiamose;[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
CBNumber: CB51401694
Molecular Formula: C46H54O16
Formula Weight: 862.92
MOL File: 187269-40-5.mol

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Bimosiamose Property

Melting point:: 115-117°
Boiling point:: 1051.0±65.0 °C(Predicted)
Density: 1.417±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM)
form: A crystalline solid
pka: 3.95±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30878
Product name: Bimosiamose
Packaging: 1mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 30878
Product name: Bimosiamose
Packaging: 5mg
Price: $311
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0008886
Product name: BIMOSIAMOSE
Purity: 95.00%
Packaging: 5MG
Price: $502.83
Updated: 2021/12/16

CSNpharm

Product number: CSN22204
Product name: Bimosiamose
Packaging: 25mg
Price: $440
Updated: 2021/12/16

CSNpharm

Product number: CSN22204
Product name: Bimosiamose
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

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Bimosiamose Chemical Properties,Usage,Production

Uses

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1].

in vivo

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved^[1].

Animal Model:	Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)^[1]
Dosage:	25 mg/kg
Administration:	Intravenous injection
Result:	Showed a significant increase in survival compared with controls.

References

[1] Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72. PMID:9328385

Bimosiamose Preparation Products And Raw materials

Raw materials

Preparation Products

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Bimosiamose Suppliers

China 19 United States 4 Global 23

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Hangzhou Jinghao Biotechnology Co., LTD

Tel: 17513242016
Fax: QQ:1576861551
Email: 1576861551@qq.com
Country: China
ProdList: 2819
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
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Jinan Luyuan Biomedical Technology Co., LTD

Tel: 13210587493
Email: jinanluyuan@hotmail.com
Country: China
ProdList: 367
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187269-40-5, BimosiamoseRelated Search:

BIPHENYLACETICACID Bimosiamose 2-(2-BIPHENYLYLOXY)ETHANOL phenyl alpha-D-mannopyranoside 3-BIPHENYL-(2'-METHOXY)ACETIC ACID

Bimosiamose

TBC-1269

[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-

187269-40-5

C46H54O16