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Bimosiamose

Product Name
Bimosiamose
CAS No.
187269-40-5
Chemical Name
Bimosiamose
Synonyms
TBC-1269;Bimosiamose;[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
CBNumber
CB51401694
Molecular Formula
C46H54O16
Formula Weight
862.92
MOL File
187269-40-5.mol
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Bimosiamose Property

Melting point:
115-117°
Boiling point:
1051.0±65.0 °C(Predicted)
Density 
1.417±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM)
form 
A crystalline solid
pka
3.95±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30878
Product name
Bimosiamose
Packaging
1mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
30878
Product name
Bimosiamose
Packaging
5mg
Price
$311
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0008886
Product name
BIMOSIAMOSE
Purity
95.00%
Packaging
5MG
Price
$502.83
Updated
2021/12/16
CSNpharm
Product number
CSN22204
Product name
Bimosiamose
Packaging
100mg
Price
$1320
Updated
2021/12/16
CSNpharm
Product number
CSN22204
Product name
Bimosiamose
Packaging
25mg
Price
$440
Updated
2021/12/16
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Bimosiamose Chemical Properties,Usage,Production

Uses

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1].

in vivo

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].

Animal Model:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
Dosage:25 mg/kg
Administration:Intravenous injection
Result:Showed a significant increase in survival compared with controls.

References

[1] Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72. PMID:9328385

Bimosiamose Preparation Products And Raw materials

Raw materials

Preparation Products

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Bimosiamose Suppliers

China 19 United States 4 Global 23
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Hangzhou Jinghao Biotechnology Co., LTD
Tel
17513242016
Fax
QQ:1576861551
Email
1576861551@qq.com
Country
China
ProdList
2819
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Jinan Luyuan Biomedical Technology Co., LTD
Tel
13210587493
Email
jinanluyuan@hotmail.com
Country
China
ProdList
367
Advantage
58
Suzhou Meishi Biotechnology Co., Ltd.
Tel
1173954148q
Email
meishipharma@126.com
Country
China
ProdList
20033
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
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58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
Email
cooperation@kean-chem.com
Country
China
ProdList
40066
Advantage
58
Watson Biotechnology Co.,Ltd
Tel
+86-18186686046 +86-18186686046;
Fax
+86-27-59524646
Email
sales01@watsonbiotech.cn
Country
China
ProdList
5746
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58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+86-18621343501; +undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33337
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58
Guangzhou Squirrel Biotechnology Co., Ltd.
Tel
17765276361
Country
CHINA
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Guangzhou Yiran Biotechnology Co., Ltd.
Tel
15571990006
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CHINA
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141
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Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
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58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
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58

187269-40-5, BimosiamoseRelated Search:

BIPHENYLACETICACID Bimosiamose 2-(2-BIPHENYLYLOXY)ETHANOL phenyl alpha-D-mannopyranoside 3-BIPHENYL-(2'-METHOXY)ACETIC ACID

  • Bimosiamose
  • TBC-1269
  • [1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
  • 187269-40-5
  • C46H54O16