ChemicalBook > CAS DataBase List > Nefazodone

Nefazodone

Product Name
Nefazodone
CAS No.
83366-66-9
Chemical Name
Nefazodone
Synonyms
SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
CBNumber
CB5144862
Molecular Formula
C25H32ClN5O2
Formula Weight
470.01
MOL File
83366-66-9.mol
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Nefazodone Property

Melting point:
180-182°C
Boiling point:
599.6±60.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ~11 mg/mL at 60 °C
form 
solid
pka
pKa 6.5 (Uncertain)
color 
white
CAS DataBase Reference
83366-66-9(CAS DataBase Reference)
NIST Chemistry Reference
Nefazodone(83366-66-9)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
Hazardous Substances Data
83366-66-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0003523
Product name
NEFAZODONE
Purity
95.00%
Packaging
1G
Price
$800
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12475
Product name
NefazodoneHCl
Packaging
10mg
Price
$845
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003523
Product name
NEFAZODONE
Purity
95.00%
Packaging
10G
Price
$4400
Updated
2021/12/16
Crysdot
Product number
CD33000073
Product name
Nefazodone
Purity
95+%
Packaging
1g
Price
$772
Updated
2021/12/16
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Nefazodone Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Dutonin,Bristol-Myers Squibb,USA

Uses

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

Definition

ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

Biological Functions

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.

Nefazodone Preparation Products And Raw materials

Raw materials

Urethane 3-Amino-5-mercapto-1,2,4-triazole Bromoethane 1-Bromo-3-chloropropane

Preparation Products

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Nefazodone Suppliers

Canada 3 China 37 Germany 2 India 2 Italy 1 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 15 USA 1 Global 66
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from Nefazodone manufacturers

Career Henan Chemical Co
Product
Nefazodone 83366-66-9
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

83366-66-9, NefazodoneRelated Search:

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  • 3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy
  • l)-5-ethyl-4-(2-phenoxyethyl)-
  • BMY-13754
  • SERZONE
  • MJ-13754-1
  • NEFAZODONE
  • 2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE
  • Nefazodone base
  • 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride
  • 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-
  • Nefazodone (base and/or unspecified salts)
  • Dutonin
  • MJ-13754-I
  • 2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one
  • 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one
  • 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
  • Nefadar
  • 83366-66-9
  • C25H32ClN5O2
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals