Methyl 2-(4-bromo-2-nitrophenyl)acetate
- Product Name
- Methyl 2-(4-bromo-2-nitrophenyl)acetate
- CAS No.
- 100487-82-9
- Chemical Name
- Methyl 2-(4-bromo-2-nitrophenyl)acetate
- Synonyms
- Methyl 4-Bromo-2-nitrophenylacetae;Methyl4-bromo-2-nitrophenylacetate98%;4-Bromo-2-nitrobenzeneacetic acid methyl ester;(4-BroMo-2-nitro-phenyl)-acetic acid Methyl ester;Benzeneacetic acid, 4-broMo-2-nitro-, Methyl ester;4-Bromo-2-nitrophenylacetic acid methyl ester, 5-Bromo-2-(2-methoxy-2-oxoethyl)nitrobenzene
- CBNumber
- CB51457611
- Molecular Formula
- C9H8BrNO4
- Formula Weight
- 274.07
- MOL File
- 100487-82-9.mol
Methyl 2-(4-bromo-2-nitrophenyl)acetate Property
- Boiling point:
- 331.7±27.0 °C(Predicted)
- Density
- 1.609±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2916391000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M296385
- Product name
- Methyl2-(4-bromo-2-nitrophenyl)acetate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR7152
- Product name
- Methyl 4-bromo-2-nitrophenylacetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 4754-9-08
- Product name
- Methyl 4-bromo-2-nitrophenylacetate
- Purity
- 98%
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- Z6282
- Product name
- Methyl2-(4-bromo-2-nitrophenyl)acetate
- Packaging
- 10g
- Price
- $419
- Updated
- 2021/12/16
- Product number
- OR7152
- Product name
- Methyl 4-bromo-2-nitrophenylacetate
- Purity
- 97%
- Packaging
- 5g
- Price
- $486
- Updated
- 2021/12/16
Methyl 2-(4-bromo-2-nitrophenyl)acetate Chemical Properties,Usage,Production
Synthesis
100487-81-8
100487-82-9
GENERAL STEPS: To a stirred solution of 1,3-dimethyl 2-(4-bromo-2-nitrophenyl) malonate (20 g, 60.2 mmol) in dimethyl sulfoxide (DMSO, 200 mL) was added lithium chloride (5.11 g, 2 eq.) followed by water (1.1 mL, 1 eq.). The reaction mixture was stirred at 100°C for 2 days and then continued at room temperature for 4 days. Upon completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (2 x 200 mL). The organic phases were combined, washed with saturated brine (2 x 200 mL) and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by Combi-Flash column chromatography (eluent: ethyl acetate/hexane) to afford methyl 2-(4-bromo-2-nitrophenyl)acetate (12 g, 73% yield) as a light yellow solid.1H NMR (400 MHz, DMSO-d6) δ 8.30 (d, J = 2.1 Hz, 1H), 7.98 (dd, J = 8.2, 2.1 Hz, 1H), 7.56 (d, J = 8.2 Hz, 1H), 4.08 (s, 2H), 3.63 (s, 3H).LCMS-ESI (POS), m/z, [M + H]+: measured values 274.0 and 276.0.
References
[1] Synthesis, 1993, # 1, p. 51 - 53
[2] Journal of the American Chemical Society, 2013, vol. 135, # 2, p. 620 - 623
[3] Patent: WO2009/158011, 2009, A1. Location in patent: Page/Page column 59-60
[4] Patent: WO2009/85040, 2009, A1. Location in patent: Page/Page column 25-26
[5] Patent: US6350747, 2002, B1. Location in patent: Page column 48
Methyl 2-(4-bromo-2-nitrophenyl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-(4-bromo-2-nitrophenyl)acetate Suppliers
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