2-chloro-5-nitropyrimidine
- Product Name
- 2-chloro-5-nitropyrimidine
- CAS No.
- 400822-47-1
- Chemical Name
- 2-chloro-5-nitropyrimidine
- Synonyms
- 3,5-Dimethyl-4-bromobenzaldehyde;Benzaldehyde, 4-bromo-3,5-dimethyl-
- CBNumber
- CB51458300
- Molecular Formula
- C9H9BrO
- Formula Weight
- 213.07
- MOL File
- 400822-47-1.mol
2-chloro-5-nitropyrimidine Property
- Boiling point:
- 279.6±28.0 °C(Predicted)
- Density
- 1.422±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to pink Solid
- InChI
- InChI=1S/C9H9BrO/c1-6-3-8(5-11)4-7(2)9(6)10/h3-5H,1-2H3
- InChIKey
- USONNBCBJMNJIU-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(C)=C(Br)C(C)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700635
- Product name
- 4-Bromo-3,5-dimethylbenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB69803
- Product name
- 4-Bromo-3,5-dimethylbenzaldehyde
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB69803
- Product name
- 4-Bromo-3,5-dimethylbenzaldehyde
- Packaging
- 1g
- Price
- $132.5
- Updated
- 2021/12/16
- Product number
- J96528
- Product name
- 4-Bromo-3,5-dimethylbenzaldehyde
- Packaging
- 5g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- J96528
- Product name
- 4-Bromo-3,5-dimethylbenzaldehyde
- Packaging
- 10g
- Price
- $490
- Updated
- 2021/12/16
2-chloro-5-nitropyrimidine Chemical Properties,Usage,Production
Synthesis
100189-84-2
68-12-2
400822-47-1
Step 1: To a solution of 2,5-dibromo m-xylene (2.0 g, 7.6 mmol) in dichloromethane (20 ml) was slowly added n-butyllithium (n-BuLi, 2.5 M hexane solution, 3 ml, 1.0 eq.) at -78 °C. The reaction mixture was stirred at -78 °C for 1 h. After that, N,N-dimethylformamide (DMF, 1.8 ml, 23 mmol, 3 eq.) was added, followed by slow warming of the reaction system to room temperature. Upon completion of the reaction, the pH was adjusted to 2 with 5% aqueous hydrochloric acid and then extracted with ether (3 x 50 ml). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether (PE):ethyl acetate (EA) = 10:1 to afford 4-bromo-3,5-dimethylbenzaldehyde (0.76 g, 47% yield).
References
[1] European Journal of Organic Chemistry, 2001, # 20, p. 3819 - 3829
[2] Patent: EP2128158, 2009, A1. Location in patent: Page/Page column 21
[3] Patent: US2008/194670, 2008, A1. Location in patent: Page/Page column 49
[4] Patent: WO2006/100631, 2006, A1. Location in patent: Page/Page column 132
[5] Dyes and Pigments, 2018, vol. 155, p. 323 - 331
2-chloro-5-nitropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-5-nitropyrimidine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 2-chloro-5-nitropyrimidine manufacturers
- Product
- 2-chloro-5-nitropyrimidine 400822-47-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg ,50kg
- Release date
- 2020-01-08