4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER
- Product Name
- 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER
- CAS No.
- 432022-88-3
- Chemical Name
- 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER
- Synonyms
- Mehtyl 4-broMo-3,5-diMethylbenzoate;4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER;BENZOIC ACID, 4-BROMO-3,5-DIMETHYL-, METHYL ESTER
- CBNumber
- CB11010595
- Molecular Formula
- C10H11BrO2
- Formula Weight
- 243.1
- MOL File
- 432022-88-3.mol
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER Property
- Boiling point:
- 310.8±37.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB67005
- Product name
- 4-Bromo-3,5-dimethylbenzoic acid methyl ester
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB67005
- Product name
- 4-Bromo-3,5-dimethylbenzoic acid methyl ester
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z1781
- Product name
- Methyl4-bromo-3,5-dimethylbenzoate
- Packaging
- 250mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FB67005
- Product name
- 4-Bromo-3,5-dimethylbenzoic acid methyl ester
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB67005
- Product name
- 4-Bromo-3,5-dimethylbenzoic acid methyl ester
- Packaging
- 2g
- Price
- $250
- Updated
- 2021/12/16
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 4-Bromo-3,5-dimethylbenzoate is a useful reagent for the preparation of benzylaminopyrazinylcyclopropanecarboxylic acid derivatives for use as GPR40 receptor activity modulators.
Synthesis
67-56-1
400822-47-1
432022-88-3
To a 250 mL round-bottomed flask was added 4-bromo-3,5-dimethylbenzaldehyde (4.0 g, 19 mmol), methanol (100 mL) and potassium iodide (623 mg, 3.8 mmol). The reaction mixture was stirred at 50 °C, followed by slow dropwise addition of tert-butyl hydroperoxide (3.9 mL, 70% aqueous solution, 28 mmol) over 30 min. After the dropwise addition, the reaction mixture was heated to reflux for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of saturated aqueous sodium thiosulfate. The reaction mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (15:1, v/v) as eluent to afford methyl 4-bromo-3,5-dimethylbenzoate as a white solid (3.8 g, 84% yield).1H NMR (400 MHz, CDCl3) δ 7.73 (s, 2H), 3.90 (s, 3H), 2.46 (s, 6H).
References
[1] Dyes and Pigments, 2018, vol. 155, p. 323 - 331
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 0510-0510-86396359 13382276200
- sales@jalor-chem.com
- Country
- China
- ProdList
- 996
- Advantage
- 56
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2965
- Advantage
- 60
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0519-85252752 15366845260
- Fax
- 86-0519-85683352
- taihuaren@vip.163.com
- Country
- China
- ProdList
- 1124
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
- Tel
- 0519-85386832 13382812559
- Fax
- 0519-85386832
- sales@cztrchem.com
- Country
- China
- ProdList
- 1185
- Advantage
- 56