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Ilaprazole

Product Name
Ilaprazole
CAS No.
172152-36-2
Chemical Name
Ilaprazole
Synonyms
Ilaprazole(IY 81149);laprazole;IY 81149;Oprazole;Ilaprazole;Blue Forest;Ilaprazole USP/EP/BP;Ilaprazole, 10 mM in DMSO;IY81149; IY-81149; IY 81149;2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol...
CBNumber
CB51459367
Molecular Formula
C19H18N4O2S
Formula Weight
366.44
MOL File
172152-36-2.mol
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Ilaprazole Property

Boiling point:
651.0±65.0 °C(Predicted)
Density 
1.39
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 10mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:7): 0.12mg/mL; Ethanol: 0.3mg/mL
form 
A solid
pka
8.23±0.10(Predicted)
color 
Off-white to gray
InChI
InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
InChIKey
HRRXCXABAPSOCP-UHFFFAOYSA-N
SMILES
C1(S(CC2=NC=CC(OC)=C2C)=O)NC2=CC(N3C=CC=C3)=CC=C2N=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2322
Product name
Ilaprazole
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$99
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2322
Product name
Ilaprazole
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$391
Updated
2025/07/31
TCI Chemical
Product number
I1191
Product name
Ilaprazole
Packaging
250MG
Price
$124
Updated
2025/07/31
TCI Chemical
Product number
I1191
Product name
Ilaprazole
Packaging
1G
Price
$311
Updated
2025/07/31
Cayman Chemical
Product number
30120
Product name
Ilaprazole
Packaging
5mg
Price
$110
Updated
2024/03/01
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Ilaprazole Chemical Properties,Usage,Production

Description

Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

Uses

Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

Definition

ChEBI: Ilaprazole is a sulfoxide and a member of benzimidazoles.

in vivo

Ilaprazole (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion[1].
In anesthetized rats, Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion. In the case of i.v. injection, the ED50 of Ilaprazole and omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED50 of Ilaprazole and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED50 is 2.1 mg/kg and that of Omeprazole is 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole is equipotent to Omeprazole. Ilaprazole also inhibits gastric acid secretion strongly in fistular rats. The ED50 of Ilaprazole administered intraduodenally is 0.43 mg/kg and that of Omeprazole is 0.68 mg/kg[1].

Animal Model:Male SD rat (after pylorus ligation)[1]
Dosage:3, 10, 30 mg/kg
Administration:Intraduodenally
Result:The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively.

Ilaprazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Ilaprazole Suppliers

China 251 India 11 United States 9 Global 271
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
NE Scientific
Tel
--
Fax
--
Country
United States
ProdList
5030
Advantage
55
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View Lastest Price from Ilaprazole manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Ilaprazole 172152-36-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-06-05
Shaanxi Dideu New Materials Co. Ltd
Product
Ilaprazole 172152-36-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-05-16
Zibo Wei Bin Import & Export Trade Co. Ltd.
Product
Ilaprazole 172152-36-2
Price
US $1.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
50kg
Release date
2023-12-08

172152-36-2, IlaprazoleRelated Search:

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  • 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole
  • IY81149; IY-81149; IY 81149
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  • 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3H-benzoimidazole USP/EP/BP
  • 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]5-(1H-pyrrol-1-yl) 1H benzimidazole
  • 2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole
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  • Blue Forest
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  • 172152-36-2
  • 172152-36-2