3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE
- Product Name
- 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE
- CAS No.
- 68716-48-3
- Chemical Name
- 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE
- Synonyms
- Pinacol 3-Nitrobenzeneboronate;3-Nitrobenzeneboronic Acid Pinacol Cycl;3-Nitrobenzeneboronic acid pinacol ester;3-NITROPHENYLBORONIC ACID, PINACOL ESTER;3 - Nitrobenzene boric acid pinacol ester;3-Nitrobenzeneboronic Acid Pinacol Cyclic Ester;4,4,5,5-TetraMethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolan;2-(3-Nitrophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;4,4,5,5-TetraMethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolane;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE
- CBNumber
- CB5146321
- Molecular Formula
- C12H16BNO4
- Formula Weight
- 249.07
- MOL File
- 68716-48-3.mol
3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE Property
- Melting point:
- 76-80 °C (lit.)
- Boiling point:
- 351.7±25.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- color
- white to off-white
- InChI
- InChI=1S/C12H16BNO4/c1-11(2)12(3,4)18-13(17-11)9-6-5-7-10(8-9)14(15)16/h5-8H,1-4H3
- InChIKey
- JWEAFTZTLIGAQU-UHFFFAOYSA-N
- SMILES
- O1C(C)(C)C(C)(C)OB1C1=CC=CC([N+]([O-])=O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 632708
- Product name
- 3-Nitrophenylboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $88
- Updated
- 2023/06/20
- Product number
- 632708
- Product name
- 3-Nitrophenylboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $221
- Updated
- 2023/06/20
- Product number
- N494320
- Product name
- 3-Nitrophenylboronic acid pinacol ester
- Packaging
- 50g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- AMTB759
- Product name
- 3-Nitrophenylboronic acid pinacol ester
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 300127
- Product name
- 3-Nitrophenylboronic acid pinacol ester, 97%
- Packaging
- 1g
- Price
- $46.2
- Updated
- 2021/12/16
3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE Chemical Properties,Usage,Production
Uses
3-Nitrophenylboronic Acid Pinacol Ester is used in the preparation of [(pyrimidoindolyl)phenyl]benzamide derivatives and analogs as Janus kinase inhibitors.
Synthesis
3-Nitrophenylboronic acid pinacol ester was prepared as follows: in a dry tubular reactor under argon, 3-nitrophenyl diazonium tetrafluoroborate (1 mmol) and ferrocene (10 mol, 1.8 mg) were dissolved in 2 mL of anhydrous CH3CN. Diisopropylaminoborane (2 mmol, 226 mg) was then added to this solution and the mixture was stirred at room temperature for 2 h 30 min. The reaction mixture (2 mL) was quenched by slow addition of anhydrous MeOH at 0 C and stirred for another 1 hour at room temperature. After removing all volatiles, 1.3 equivalents of pinacol were added to Et2O (2 mL) and the mixture was stirred at room temperature for 4 hours. The crude mixture was washed with 50 g / L CuCl2 solution (2 x 5 mL). The organic layer was separated, dried with Na2SO4, filtered and concentrated to dryness. The resulting oil was dissolved with CH2Cl 2 and filtered through a silica gel pad, eluting with CH2Cl2 to give the corresponding boronic acid ester 3-nitrophenylboronic acid pinacol ester.
3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE manufacturers
- Product
- 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE 68716-48-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30