CETRORELIX

ChemicalBook > CAS DataBase List > CETRORELIX

Product Name: CETRORELIX
CAS No.: 145672-81-7
Chemical Name: CETRORELIX
Synonyms: Cetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate);Cetrorelix acetate (SB-75);Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%
CBNumber: CB51478311
Molecular Formula: C70H92ClN17O14.C2H4O2
Formula Weight: 1491.11
MOL File: 145672-81-7.mol

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CETRORELIX Property

storage temp.: -20°C
solubility: methanol: soluble10%
form: solid
Water Solubility: Soluble in water

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Safety

Risk Statements: 60-63
Safety Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5249
Product name: Cetrorelix acetate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: C5249
Product name: Cetrorelix acetate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $516
Updated: 2024/03/01

Cayman Chemical

Product number: 23910
Product name: Cetrorelix (acetate)
Purity: ≥95%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 23910
Product name: Cetrorelix (acetate)
Purity: ≥95%
Packaging: 5mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 23910
Product name: Cetrorelix (acetate)
Purity: ≥95%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

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CETRORELIX Chemical Properties,Usage,Production

Description

Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a K_d value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp⁶]GnRH (IC₅₀ = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model. Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control. Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.

Uses

Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.

Uses

Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.

Definition

ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.

Biochem/physiol Actions

Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss.

storage

Store at -20°C

CETRORELIX Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CETRORELIX manufacturers

Longyan Tianhua Biological Technology Co., Ltd

Product: CETRORELIX 145672-81-7
Price: US $15.00/g
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-10-27

Career Henan Chemical Co

Product: CETRORELIX 145672-81-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kG
Release date: 2019-07-04

145672-81-7, CETRORELIXRelated Search:

CETRORELIX CETRORELIX cetrorelix Acetylated cetrorelix NA CETRORELIX ACETATE (Sitraric Acetate) Deamidated cetrorelix AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-NH2, ACETATE Cetrorelix trifluoroacetate Cetrorelix acetate Cetrorelix acetate

D 20761

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt)

Ns 75a

Sb 075 acetate

Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%

Cetrorelix impurity

SB-075 ACETATE;NS-75A

Cetrotid

Ovurelix

N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt

Cetrorelix( x acetate)

Cetrorelix acetate (SB-75)

Cetrorelix AcetateQ: What is Cetrorelix Acetate Q: What is the CAS Number of Cetrorelix Acetate Q: What is the storage condition of Cetrorelix Acetate Q: What are the applications of Cetrorelix Acetate

SB-75,GnRH Receptor,Cetrorelix Acetate,Inhibitor,SB 75,Gonadotropin releasing hormone receptor,inhibit,SB75,GNRHR

(S)-N-((R)-1-Amino-1-oxopropan-2-yl)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-chlorobenzyl)-2-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-8-(3-ureid

145672-81-7

C70H92ClN17O14xC2H4O2

Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals