2-BROMO-5-HYDROXYBENZONITRILE
- Product Name
- 2-BROMO-5-HYDROXYBENZONITRILE
- CAS No.
- 189680-06-6
- Chemical Name
- 2-BROMO-5-HYDROXYBENZONITRILE
- Synonyms
- 2-BroMo-5-hydroxybenzonitrle;Benzonitrile, 2-bromo-5-hydroxy-
- CBNumber
- CB51484598
- Molecular Formula
- C7H4BrNO
- Formula Weight
- 198.02
- MOL File
- 189680-06-6.mol
2-BROMO-5-HYDROXYBENZONITRILE Property
- Boiling point:
- 321.2±32.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.01±0.18(Predicted)
- form
- powder
- color
- Brown
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B684590
- Product name
- 2-Bromo-5-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 072381
- Product name
- 2-Bromo-5-hydroxybenzonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- FB70711
- Product name
- 2-Bromo-5-hydroxybenzonitrile
- Packaging
- 5G
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB70711
- Product name
- 2-Bromo-5-hydroxybenzonitrile
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W4082
- Product name
- 2-Bromo-5-hydroxybenzonitrile
- Packaging
- 10g
- Price
- $212
- Updated
- 2021/12/16
2-BROMO-5-HYDROXYBENZONITRILE Chemical Properties,Usage,Production
Uses
2-Bromo-5-hydroxybenzonitrile is a reagent used in the synthesis of various pharmaceutical goods.
Synthesis
873-62-1
189680-06-6
Step 1: Bromination reaction 3-Hydroxybenzonitrile (3.2 g, 26.8 mmol) was dissolved in glacial acetic acid (20 ml) and acetic acid solution (5 ml) of bromine (4.2 g, 23.3 mmol) was added slowly dropwise for a controlled period of 5 minutes. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was filtered. The filtrate was poured into water (100 ml) containing a small amount of sodium thiosulfate to quench the unreacted bromine. The insoluble material was collected and the filter cake was mixed with warm methanol (15 ml) and filtered through diatomaceous earth. The filtrate was slowly diluted with water to precipitate, the precipitate was collected and dried to give 2-bromo-5-hydroxybenzonitrile in 22% yield (1.0 g) with a melting point of 183-185 °C.
References
[1] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 2, p. 120 - 124
[2] Patent: WO2011/34828, 2011, A1. Location in patent: Page/Page column 80
[3] Patent: WO2004/35556, 2004, A1. Location in patent: Page 95
2-BROMO-5-HYDROXYBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-HYDROXYBENZONITRILE manufacturers
- Product
- 2-BROMO-5-HYDROXYBENZONITRILE 189680-06-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-12-19