ChemicalBook > CAS DataBase List > 2,4-DICHLORO-6-FLUOROQUINAZOLINE

2,4-DICHLORO-6-FLUOROQUINAZOLINE

Product Name: 2,4-DICHLORO-6-FLUOROQUINAZOLINE
CAS No.: 134517-57-0
Chemical Name: 2,4-DICHLORO-6-FLUOROQUINAZOLINE
Synonyms: 4-dichloro-6-fluoroquinazoline;2,4-Dichloro-6-fluoroquinazolin;2,4-dichloro-6-fluoroquinazoline;Quinazoline, 2,4-dichloro-6-fluoro-;2,4-dichloro-6-fluoroquinazoline 97+%
CBNumber: CB51501961
Molecular Formula: C8H3Cl2FN2
Formula Weight: 217.03
MOL File: 134517-57-0.mol

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2,4-DICHLORO-6-FLUOROQUINAZOLINE Property

Boiling point:: 277.3±22.0 °C(Predicted)
Density: 1.571±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.09±0.30(Predicted)
Appearance: White to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B419270
Product name: 2,4-Dichloro-6-fluoroquinazoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B419270
Product name: 2,4-Dichloro-6-fluoroquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC502106
Product name: 2,4-dichloro-6-fluoroquinazoline
Purity: 97+%
Packaging: 1g
Price: $71
Updated: 2021/12/16

Matrix Scientific

Product number: 057314
Product name: 2,4-Dichloro-6-fluoroquinazoline
Purity: 97%
Packaging: 1g
Price: $74
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-8J
Product name: 2,4-Dichloro-6-fluoroquinazoline
Packaging: 1g
Price: $114
Updated: 2021/12/16

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2,4-DICHLORO-6-FLUOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

88145-90-8

134517-57-0

(Step 2) Synthesis of 2,4-dichloro-6-fluoroquinazoline: Phosphorus pentachloride (12.5 g, 60.0 mmol) was added to phosphorus trichloride (46.0 mL, 502.5 mmol), followed by the slow addition of 6-fluoroquinazoline-2,4(1H,3H)-dione (3.6 g, 20.0 mmol) under stirring. The reaction mixture was heated to reflux and stirred for 9 hours. After completion of the reaction, the mixture was cooled and the solvent was removed under vacuum. An ice-water mixture (400 mL) was added to the residue and stirring was continued for 0.5 hours. The mixture was extracted with dichloromethane (DCM, 250 mL x 3). The DCM layers were combined, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=30/1) to afford the title compound 2,4-dichloro-6-fluoroquinazoline as a white solid (3.735 g, 86.0% yield). m/z MS (ESI, cationic): 216.9 [M + H]+; 1H NMR (CDCl3, 400 MHz) δ ( ppm): 8.03 (dd, J=9.2 Hz, 4.9 Hz, 1H), 7.86 (dd, J=8.1 Hz, 2.7 Hz, 1H), 7.79-7.73 (m, 1H).

References

[1] Patent: WO2017/12502, 2017, A1. Location in patent: Page/Page column 52
[2] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00214
[3] Patent: CN105949203, 2016, A. Location in patent: Paragraph 0179; 0185; 0186
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7717 - 7727
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865

2,4-DICHLORO-6-FLUOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-DICHLORO-6-FLUOROQUINAZOLINE manufacturers

Career Henan Chemical Co

Product: 2,4-DICHLORO-6-FLUOROQUINAZOLINE 134517-57-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

134517-57-0, 2,4-DICHLORO-6-FLUOROQUINAZOLINERelated Search:

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134517-57-0