2,4-DICHLORO-6-FLUOROQUINAZOLINE
- Product Name
- 2,4-DICHLORO-6-FLUOROQUINAZOLINE
- CAS No.
- 134517-57-0
- Chemical Name
- 2,4-DICHLORO-6-FLUOROQUINAZOLINE
- Synonyms
- 4-dichloro-6-fluoroquinazoline;2,4-Dichloro-6-fluoroquinazolin;2,4-dichloro-6-fluoroquinazoline;Quinazoline, 2,4-dichloro-6-fluoro-;2,4-dichloro-6-fluoroquinazoline 97+%
- CBNumber
- CB51501961
- Molecular Formula
- C8H3Cl2FN2
- Formula Weight
- 217.03
- MOL File
- 134517-57-0.mol
2,4-DICHLORO-6-FLUOROQUINAZOLINE Property
- Boiling point:
- 277.3±22.0 °C(Predicted)
- Density
- 1.571±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.09±0.30(Predicted)
- Appearance
- White to yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419270
- Product name
- 2,4-Dichloro-6-fluoroquinazoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B419270
- Product name
- 2,4-Dichloro-6-fluoroquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 057314
- Product name
- 2,4-Dichloro-6-fluoroquinazoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
- Product number
- PC502106
- Product name
- 2,4-dichloro-6-fluoroquinazoline
- Purity
- 97+%
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- 057314
- Product name
- 2,4-Dichloro-6-fluoroquinazoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
2,4-DICHLORO-6-FLUOROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
88145-90-8
134517-57-0
(Step 2) Synthesis of 2,4-dichloro-6-fluoroquinazoline: Phosphorus pentachloride (12.5 g, 60.0 mmol) was added to phosphorus trichloride (46.0 mL, 502.5 mmol), followed by the slow addition of 6-fluoroquinazoline-2,4(1H,3H)-dione (3.6 g, 20.0 mmol) under stirring. The reaction mixture was heated to reflux and stirred for 9 hours. After completion of the reaction, the mixture was cooled and the solvent was removed under vacuum. An ice-water mixture (400 mL) was added to the residue and stirring was continued for 0.5 hours. The mixture was extracted with dichloromethane (DCM, 250 mL x 3). The DCM layers were combined, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=30/1) to afford the title compound 2,4-dichloro-6-fluoroquinazoline as a white solid (3.735 g, 86.0% yield). m/z MS (ESI, cationic): 216.9 [M + H]+; 1H NMR (CDCl3, 400 MHz) δ ( ppm): 8.03 (dd, J=9.2 Hz, 4.9 Hz, 1H), 7.86 (dd, J=8.1 Hz, 2.7 Hz, 1H), 7.79-7.73 (m, 1H).
References
[1] Patent: WO2017/12502, 2017, A1. Location in patent: Page/Page column 52
[2] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00214
[3] Patent: CN105949203, 2016, A. Location in patent: Paragraph 0179; 0185; 0186
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7717 - 7727
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865
2,4-DICHLORO-6-FLUOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DICHLORO-6-FLUOROQUINAZOLINE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 2,4-DICHLORO-6-FLUOROQUINAZOLINE manufacturers
- Product
- 2,4-DICHLORO-6-FLUOROQUINAZOLINE 134517-57-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25