ChemicalBook > CAS DataBase List > (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

Product Name
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
CAS No.
119770-60-4
Chemical Name
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
Synonyms
Des Loratadine methanone;Loratadine Methyl Ketone;Loratadine Impurity 10 HCl;Loratadine Impurity 36 HCl;Loratadine Impurity 39 HCl;Loratadine Methanone Impurity;(3-(3-chlorophenethyl)pyridin-;Desloratadine Methanone Impurity;Desloratadine?Methanone?Impurity?HCl;(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
CBNumber
CB51503925
Molecular Formula
C20H24Cl2N2O
Formula Weight
379.32
MOL File
119770-60-4.mol
More
Less

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Property

Melting point:
183-185 °C
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
82364
Product name
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone
Packaging
1mg
Price
$490
Updated
2021/12/16
Chemenu
Product number
CM175915
Product name
(3-(3-chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride
Purity
95%
Packaging
1g
Price
$916
Updated
2021/12/16
Crysdot
Product number
CD11333995
Product name
(3-(3-Chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride
Purity
95+%
Packaging
1g
Price
$972
Updated
2021/12/16
More
Less

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Chemical Properties,Usage,Production

Uses

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research.

Synthesis

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Suppliers

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd
Tel
18072846723; 18072846723
Email
caigou1@witofly.com
Country
China
ProdList
3037
Advantage
58
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5902
Advantage
65
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Shanghai Witofly Chemical Co. ,Ltd.
Tel
021-5063062 15300832537
Email
sales@witofly.com
Country
China
ProdList
1603
Advantage
55
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Shanghai Fuyi Biological Technology Co., Ltd.
Tel
18096642264
Email
sales@foreversyn.com
Country
China
ProdList
492
Advantage
58
More
Less

View Lastest Price from (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Desloratadine Methanone Impurity 119770-60-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13
Henan Aochuang Chemical Co.,Ltd.
Product
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride 119770-60-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

119770-60-4, (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochlorideRelated Search:


  • (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
  • [3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl](1-methyl-4-piperidinyl)methanone hydrochloride
  • (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methyl-piperidin-4-yl)methanone hydrochloride
  • Loratadine Methanone Impurity
  • [3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]-(1-methylpiperidin-4-yl)methanone:hydrochloride
  • Loratadine Impurity 10 HCl
  • Desloratadine Methanone Impurity
  • (3-(3-chlorophenethyl)pyridin-
  • Loratadine Impurity ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone)
  • {3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl?piperidine-4-yl) (Methonal HCL)
  • Des Loratadine methanone
  • Desloratadine Impurity 3/Desloratadine Methanone Impurity HCl/Desloratadine Ketone Impurity HCl
  • Loratadine Methyl Ketone
  • (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride ISO 9001:2015 REACH
  • Loratadine Methanone Impurity (Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity)
  • Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity (Loratadine Methanone Impurity)
  • (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
  • Loratadine Impurity 36 HCl
  • Desloratadine?Methanone?Impurity?HCl
  • (1-methyl-4-piperidinyl) [3- [2- (3-chlorophenyl) ethyl] pyridin-2-yl] ketone hydrochloride
  • Loratadine Impurity 39 HCl
  • {3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl}(4- methylcyclohexyl)methanone
  • 119770-60-4
  • C20H24Cl2N2O