(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
- Product Name
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
- CAS No.
- 119770-60-4
- Chemical Name
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
- Synonyms
- Des Loratadine methanone;Loratadine Methyl Ketone;Loratadine Impurity 10 HCl;Loratadine Impurity 36 HCl;Loratadine Impurity 39 HCl;Loratadine Methanone Impurity;(3-(3-chlorophenethyl)pyridin-;Desloratadine Methanone Impurity;Desloratadine?Methanone?Impurity?HCl;(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
- CBNumber
- CB51503925
- Molecular Formula
- C20H24Cl2N2O
- Formula Weight
- 379.32
- MOL File
- 119770-60-4.mol
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Property
- Melting point:
- 183-185 °C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 82364
- Product name
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone
- Packaging
- 1mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- CM175915
- Product name
- (3-(3-chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $916
- Updated
- 2021/12/16
- Product number
- CD11333995
- Product name
- (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $972
- Updated
- 2021/12/16
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Chemical Properties,Usage,Production
Uses
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research.
Synthesis
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Suppliers
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View Lastest Price from (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride manufacturers
- Product
- Desloratadine Methanone Impurity 119770-60-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-13
- Product
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride 119770-60-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10