(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Product Name: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
CAS No.: 330156-50-8
Chemical Name: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Synonyms: 100968;Crizotinib Impurity 5;Crizotinib Impurity E;Crizotinib InterMediate;6-Dichloro-3-fluorophenyl)ethanol;(R)-2,6-Dichloro-3-fluoro-α(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(R)-2,6-Dichloro-3-fluoro-α-methylbenzyl Alcohol
CBNumber: CB51503930
Molecular Formula: C8H7Cl2FO
Formula Weight: 209.04
MOL File: 330156-50-8.mol

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(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Property

Melting point:: 41.0 to 45.0 °C
Boiling point:: 261 °C
Density: 1.406
Flash point:: 112 °C
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 13.30±0.20(Predicted)
color: White to Almost white
InChI: InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey: JAOYKRSASYNDGH-SCSAIBSYSA-N
SMILES: C1([C@@H](C)O)=C(Cl)C=CC(F)=C1Cl |&1:1,r|

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Safety

HS Code: 2906.29.6000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4577
Product name: (R)-2,6-Dichloro-3-fluoro-alpha-methylbenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: D4577
Product name: (R)-2,6-Dichloro-3-fluoro-alpha-methylbenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: D434238
Product name: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Packaging: 5g
Price: $165
Updated: 2021/12/16

TRC

Product number: D434238
Product name: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Packaging: 50g
Price: $800
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0051077
Product name: (1R)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHAN-1-OL
Purity: 95.00%
Packaging: 1G
Price: $983.52
Updated: 2021/12/16

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(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Usage,Production

Description

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an alcohol derivative and can be used as a pharmaceutical intermediate.

Uses

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is used in the synthesis of anti-tumor molecular targeted drug of Crizotinib (C785000).

Synthesis

756520-66-8

330156-50-8

1. Primary crystallization: 30 g of 1-(2,6-dichloro-3-fluorophenyl)ethanol was dissolved in 105 mL of petroleum ether and heated and stirred under argon protection for 40 minutes until complete dissolution. (R)-1-(2,6-dichloro-3-fluorophenyl)ethanol crystal seed was added, and the crystal seed was observed to become smaller after 45 min; the crystal seed completely disappeared after 1 h; a white solid precipitate precipitated after 3.5 h (precipitated to the bottom); the reaction was stopped after 10 h, and no further separation was required. Filtration and drying gave 22 g of product in 73.3% yield. The enantiomeric excess (ee) was 62.5% as detected by chiral chromatography. 2. Secondary crystallization: 30 g of the primary crystallization product was dissolved in 105 mL of petroleum ether and heated and stirred under argon protection for 45 min until complete dissolution. Add (R)-1-(2,6-dichloro-3-fluorophenyl)ethanol crystalline seed, after 45 minutes, the crystalline seed was observed to become smaller; after 1 hour, the crystalline seed completely disappeared; after 3.5 hours, a white solid precipitate precipitated (precipitated to the bottom); after 10 hours, the reaction was stopped, and there was no need for further separation. Filtration and drying gave 22 g of product in 73.3% yield. The enantiomeric excess (ee) was 95.0% by chiral chromatography. 3. Tertiary crystallization: 30 g of the secondary crystallization product was dissolved in 105 mL of petroleum ether and heated and stirred under argon protection for 40 min until complete dissolution. 45 min later, (R)-1-(2,6-dichloro-3-fluorophenyl)ethanol crystals were added; the crystals disappeared completely after 1 h; a white solid precipitate precipitated (to the bottom of the precipitate) after 3.5 h; the reaction was stopped after 10 h, and there was no need for further separation. The reaction was stopped after 10 hours without further separation. The reaction was stopped after 10 hours without further separation. 23 g of the product was obtained by filtration and drying, with a yield of 76.7%. The enantiomeric excess (ee) was 99.6% by chiral chromatography.

References

[1] Patent: CN105237346, 2016, A. Location in patent: Paragraph 0062; 0063; 0064; 0065; 0066; 0067; 0068-0069
[2] Patent: WO2012/48259, 2012, A2. Location in patent: Page/Page column 37
[3] Patent: WO2012/48258, 2012, A2. Location in patent: Page/Page column 30
[4] Patent: WO2013/17989, 2013, A1

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Suppliers

Americas 1 China 151 Europe 1 India 5 Japan 1 United Kingdom 2 United States 15 Global 176

TCI Chemicals (India) Pvt. Ltd.

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Ethachem

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Reax Chemicals

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OctaneX Labs

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A.J Chemicals

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ProdList: 6100
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View Lastest Price from (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 330156-50-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

LY Global chemicals co.,ltd .

Product: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 330156-50-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 330156-50-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

330156-50-8, (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanolRelated Search:

Ethanol Dichlorodiphenylsilane 2-Fluoroethanol Phenethyl alcohol Ethyl acetate 2,2,2-TRIFLUOROETHANOL-D3 Dichloromethylphenylsilane Dichlorofluoroethane 2,6-Dichloro-3-fluoroacetophenone (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 1-(2,6-DICHLOROPHENYL)ETHANOL 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Crizotinib Impurity 5

100968

benzeneMethanol, 2,6-dichloro-3-fluoro-α-Methyl-, (alphaR)-

BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aR)-

Crizotinib InterMediate

Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αR)-

(R)-2,6-Dichloro-3-fluoro-alpha-methylbenzyl Alcohol

<i>(R)</i>-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(<i>R</i>)-2,6-Dichloro-3-fluoro-&alpha

(R)-2,6-Dichloro-3-fluoro-α-methylbenzyl Alcohol

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

Crizotinib Impurity E

(1R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

(R)-2,6-Dichloro-3-fluoro-α-methylbenzyl Alcohol &gt

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ISO 9001：2015 REACH

6-Dichloro-3-fluorophenyl)ethanol

(αR)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol

(alphaR)-2,6-Dichloro-3-fluoro-alpha-methylbenzenemethanol

330156-50-8

Chiral Compounds