(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Product Name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
CAS No.: 877397-65-4
Chemical Name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Synonyms: (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
CBNumber: CB11503932
Molecular Formula: C8H7Cl2FO
Formula Weight: 209.04
MOL File: 877397-65-4.mol

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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Property

Boiling point:: 261.3±35.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.30±0.20(Predicted)
form: Solid
color: White
InChI: InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey: JAOYKRSASYNDGH-UFLUHPNLNA-N
SMILES: [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
CAS DataBase Reference: 877397-65-4

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Safety

HazardClass: IRRITANT
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H65374
Product name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging: 1g
Price: $61.2
Updated: 2023/06/20

Alfa Aesar

Product number: H65374
Product name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging: 5g
Price: $273
Updated: 2023/06/20

Alfa Aesar

Product number: H65374
Product name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging: 250mg
Price: $17.4
Updated: 2021/12/16

TRC

Product number: D434235
Product name: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Packaging: 50g
Price: $1075
Updated: 2021/12/16

ChemScene

Product number: CS-M0263
Product name: (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol
Purity: 99.98%
Packaging: 100g
Price: $517
Updated: 2021/12/16

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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Usage,Production

Uses

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor ( c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

Uses

(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).

Uses

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

Synthesis

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Suppliers

Canada 1 China 276 India 2 United Kingdom 3 United States 11 Global 293

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

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View Lastest Price from (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers

Henan Fengda Chemical Co., Ltd

Product: (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Nanjing Fred Technology Co., Ltd

Product: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞98% by HPLC
Supply Ability: 10kg/month
Release date: 2023-01-09

877397-65-4, (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanolRelated Search:

Phenethyl alcohol 2-Methoxyethanol 2,2,2-TRIFLUOROETHANOL-D3 Dichlorofluoroethane Ethanol 2-AMINO-1-PHENYLETHANOL Dichlorodiphenylsilane Ethyl acetate Perfluoroalkyl alcohol Dichloromethylphenylsilane (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Crizotinib (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 1-(2,6-DICHLOROPHENYL)ETHANOL Dichlorodifluoromethane (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL

BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)-

(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol

(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol

(aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol

-1-(2,6-Dichloro-3-fluorophenyl)

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano

JACS-877397-65-4

(S)-1-(2,6-DichL

Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αS)-

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ISO 9001：2015 REACH

Crizotinib Interm 7654

(αS)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol

(S)-l-(2,6-Dichl〇T〇-3 -fluorophenyl)ethanolethanol

877397-65-4

877399-65-4

Aromatic Ring

Chiral Compounds