(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Product Name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- CAS No.
- 877397-65-4
- Chemical Name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Synonyms
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
- CBNumber
- CB11503932
- Molecular Formula
- C8H7Cl2FO
- Formula Weight
- 209.04
- MOL File
- 877397-65-4.mol
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Property
- Boiling point:
- 261.3±35.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.30±0.20(Predicted)
- form
- Solid
- color
- White
- InChI
- InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
- InChIKey
- JAOYKRSASYNDGH-UFLUHPNLNA-N
- SMILES
- [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
- CAS DataBase Reference
- 877397-65-4
Safety
- HazardClass
- IRRITANT
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H65374
- Product name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
- Packaging
- 1g
- Price
- $61.2
- Updated
- 2023/06/20
- Product number
- H65374
- Product name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
- Packaging
- 5g
- Price
- $273
- Updated
- 2023/06/20
- Product number
- H65374
- Product name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
- Packaging
- 250mg
- Price
- $17.4
- Updated
- 2021/12/16
- Product number
- D434235
- Product name
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Packaging
- 50g
- Price
- $1075
- Updated
- 2021/12/16
- Product number
- CS-M0263
- Product name
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol
- Purity
- 99.98%
- Packaging
- 100g
- Price
- $517
- Updated
- 2021/12/16
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Usage,Production
Uses
(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).
Uses
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Synthesis
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Suppliers
View Lastest Price from (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers
- Product
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 10g
- Purity
- 99%+
- Supply Ability
- 10000KG
- Release date
- 2019-12-25
- Product
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-29
- Product
- (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31