4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

Product Name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.: 877399-50-3
Chemical Name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
Synonyms: CRIXOTINIB-D;1-Boc-4-(4-br;Crizotinib Impurity 4;1-(4-BOC-Piperidino)-4-bromopyrazole;1-Boc-4-(4-broMopyrazol-1-yl)piperidine;1-Boc-4-(4-bromo-1-pyrazolyl)piperidine;N-BOC-4-(4-BROMOPYRAZOL-1-YL)PIPERIDINE;1-(4-Boc-1-piperidinyl)-4-bromopyrazole;1-Boc-4-(4-bromo-1H-pyrazol-1-yl)piperidine;4-Bromo-1-(N-boc-piperidin-4-yl)-1H-pyrazole
CBNumber: CB21504512
Molecular Formula: C13H20BrN3O2
Formula Weight: 330.22
MOL File: 877399-50-3.mol

More

Less

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Property

Melting point:: 77.0 to 81.0 °C
Boiling point:: 411.5±35.0 °C(Predicted)
Density: 1.43
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 0.92±0.19(Predicted)
form: Solid
color: Off-white
InChI: 1S/C13H20BrN3O2/c1-13(2,3)19-12(18)16-6-4-11(5-7-16)17-9-10(14)8-15-17/h8-9,11H,4-7H2,1-3H3
InChIKey: IYNZAVDBHAQODX-UHFFFAOYSA-N
SMILES: CC(C)(C)OC(=O)N1CCC(CC1)n2cc(Br)cn2
CAS DataBase Reference: 877399-50-3

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B4391
Product name: tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: B4391
Product name: tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $191
Updated: 2024/03/01

TRC

Product number: B662025
Product name: 1-(4-BOC-Piperidino)-4-bromopyrazole
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 083924
Product name: tert-Butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB34117
Product name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
Packaging: 5G
Price: $60
Updated: 2021/12/16

More

Less

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

2075-45-8

141699-59-4

877399-50-3

General procedure for the synthesis of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate from 4-bromopyrazole and tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate: 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 4 liters of N-methyl pyrrolidinone, and heated to 80°C. Subsequently, 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 5 liters of N-methyl pyrrolidinone. 1.8 kg of tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate was added to the reaction mixture and the reaction lasted for 12 hours. After completion of the reaction, it was cooled to room temperature, 50 liters of methyl tert-butyl ether and 50 liters of water were added and stirred for 1 hour. After separating the organic phase, the organic phase was washed 4 times with 20 liters of water, then dried with 50% hexane and stirred for 2 hours at room temperature. Finally, it was filtered and dried to give 1.35 kg of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate in 77% yield.

References

[1] Patent: CN106317024, 2017, A. Location in patent: Paragraph 0060; 0061
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4092 - 4108
[3] Patent: WO2015/81257, 2015, A2. Location in patent: Page/Page column 81
[4] Tetrahedron Letters, 2014, vol. 55, # 9, p. 1528 - 1531
[5] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 64-65

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Suppliers

Americas 1 China 155 Europe 1 India 6 Japan 1 Switzerland 1 United Kingdom 3 United States 19 Global 187

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: marketing@accelachem.com
Country: China
ProdList: 10977
Advantage: 64

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981 13982130196;
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 852
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

More

Less

View Lastest Price from 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 877399-50-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-29

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(4-BOC-Piperidino)-4-broMopyrazole 877399-50-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Henan Fengda Chemical Co., Ltd

Product: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate 877399-50-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

877399-50-3, 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl esterRelated Search:

Tris(trimethylsilyl)phosphate tert-Butyl carbazate 2-Butoxyethanol Butylparaben Butyl acetate Isobutyl chloroformate tert-Butyl bromoacetate Methyl acrylate Diisobutyl phthalate Butyl acrylate tert-Butyl peroxybenzoate Butyl benzoate Buprofezin Piperidine 4-Bromopyrazole TERT-BUTYL FORMATE 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester CARBOXYLIC ACID

4-(4-Bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

Crizotinib Impurity 4

CRIXOTINIB-D

4-Bromo-1-(N-boc-piperidin-4-yl)-1H-pyrazole

1-Boc-4-(4-bromo-1-pyrazolyl)piperidine

1-(4-BOC-Piperidino)-4-bromopyrazole

(R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-a

1-Boc-4-(4-broMopyrazol-1-yl)piperidine

tert-butyl 4-(4-broMo-1H-pyrazol-1-yl)piperidine-1-carbo×ylate

1-Piperidinecarboxylicacid, 4-(4-broMo-1H-pyrazol-1-yl)-, 1,1-diMethylethyl ester

tert-Butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate

1-Boc-4-(4-bromo-1H-pyrazol-1-yl)piperidine

<i>tert</i>-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate

N-BOC-4-(4-BROMOPYRAZOL-1-YL)PIPERIDINE

1-Boc-4-(4-br

1-(4-Boc-1-piperidinyl)-4-bromopyrazole

4-(4-bromo-1-pyrazolyl)-1-piperidinecarboxylic acid tert-butyl ester

tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate &gt

1-tert-Butoxycarbonyl-4-(4-bromopyrazol-1-yl)piperidine

Tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylat

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-but...

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate

877399-50-3

C13H20O2N3Br

C13H20BrN3O2

intermediate

API intermediates