4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

Product Name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.: 877399-50-3
Chemical Name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
Synonyms: CRIXOTINIB-D;1-Boc-4-(4-br;Crizotinib Impurity 4;1-(4-BOC-Piperidino)-4-bromopyrazole;1-Boc-4-(4-broMopyrazol-1-yl)piperidine;1-Boc-4-(4-bromo-1-pyrazolyl)piperidine;N-BOC-4-(4-BROMOPYRAZOL-1-YL)PIPERIDINE;1-(4-Boc-1-piperidinyl)-4-bromopyrazole;1-Boc-4-(4-bromo-1H-pyrazol-1-yl)piperidine;4-Bromo-1-(N-boc-piperidin-4-yl)-1H-pyrazole
CBNumber: CB21504512
Molecular Formula: C13H20BrN3O2
Formula Weight: 330.22
MOL File: 877399-50-3.mol

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4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Property

Melting point:: 77.0 to 81.0 °C
Boiling point:: 411.5±35.0 °C(Predicted)
Density: 1.43
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Solid
pka: 0.92±0.19(Predicted)
color: Off-white
CAS DataBase Reference: 877399-50-3

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4391
Product name: tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: B4391
Product name: tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $191
Updated: 2024/03/01

TRC

Product number: B662025
Product name: 1-(4-BOC-Piperidino)-4-bromopyrazole
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 083924
Product name: tert-Butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB34117
Product name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
Packaging: 5G
Price: $60
Updated: 2021/12/16

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4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

2075-45-8

141699-59-4

877399-50-3

General procedure for the synthesis of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate from 4-bromopyrazole and tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate: 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 4 liters of N-methyl pyrrolidinone, and heated to 80°C. Subsequently, 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 5 liters of N-methyl pyrrolidinone. 1.8 kg of tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate was added to the reaction mixture and the reaction lasted for 12 hours. After completion of the reaction, it was cooled to room temperature, 50 liters of methyl tert-butyl ether and 50 liters of water were added and stirred for 1 hour. After separating the organic phase, the organic phase was washed 4 times with 20 liters of water, then dried with 50% hexane and stirred for 2 hours at room temperature. Finally, it was filtered and dried to give 1.35 kg of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate in 77% yield.

References

[1] Patent: CN106317024, 2017, A. Location in patent: Paragraph 0060; 0061
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4092 - 4108
[3] Patent: WO2015/81257, 2015, A2. Location in patent: Page/Page column 81
[4] Tetrahedron Letters, 2014, vol. 55, # 9, p. 1528 - 1531
[5] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 64-65

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

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View Lastest Price from 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 877399-50-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-29

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(4-BOC-Piperidino)-4-broMopyrazole 877399-50-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Henan Fengda Chemical Co., Ltd

Product: tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate 877399-50-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

877399-50-3, 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl esterRelated Search:

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4-(4-Bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

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1-Boc-4-(4-br

1-(4-Boc-1-piperidinyl)-4-bromopyrazole

4-(4-bromo-1-pyrazolyl)-1-piperidinecarboxylic acid tert-butyl ester

tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate &gt

1-tert-Butoxycarbonyl-4-(4-bromopyrazol-1-yl)piperidine

Tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylat

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-but...

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate

877399-50-3

C13H20O2N3Br

C13H20BrN3O2

intermediate

API intermediates