4-Bromopyrazole

Product Name: 4-Bromopyrazole
CAS No.: 2075-45-8
Chemical Name: 4-Bromopyrazole
Synonyms: 4-BROMO-1H-PYRAZOLE;DK660;93℃-96℃;NSC 522023;AKOS B001462;WLN: T5MNJ DE;4-Brompyrazole;4-BROMOPYRAZOLE;4-bromo-pyrazol;Baricitinib-001
CBNumber: CB6158239
Molecular Formula: C3H3BrN2
Formula Weight: 146.97
MOL File: 2075-45-8.mol

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4-Bromopyrazole Property

Melting point:: 93-96 °C (lit.)
Boiling point:: 250-260 °C (lit.)
Density: 1.5979 (rough estimate)
refractive index: 1.5260 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, DMSO, Methanol
form: Crystalline Powder
pka: 12.71±0.50(Predicted)
color: White to cream
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C3H3BrN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey: FHZALEJIENDROK-UHFFFAOYSA-N
SMILES: N1C=C(Br)C=N1
CAS DataBase Reference: 2075-45-8(CAS DataBase Reference)
NIST Chemistry Reference: 1H-pyrazole, 4-bromo-(2075-45-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: UQ6200000
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 374822
Product name: 4-Bromopyrazole
Purity: 99%
Packaging: 1g
Price: $21.36
Updated: 2025/07/31

Sigma-Aldrich

Product number: 374822
Product name: 4-Bromopyrazole
Purity: 99%
Packaging: 10g
Price: $256
Updated: 2025/07/31

TCI Chemical

Product number: B3745
Product name: 4-Bromopyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B3745
Product name: 4-Bromopyrazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $86
Updated: 2025/07/31

TRC

Product number: B687110
Product name: 4-Bromo-1H-pyrazole
Packaging: 1g
Price: $110
Updated: 2021/12/16

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4-Bromopyrazole Chemical Properties,Usage,Production

Chemical Properties

White to cream crystalline powder

Uses

4-Bromopyrazole can be used as starting material employed in a synthesis of 1,4′-bipyrazoles and in suzuki reaction.

Uses

As a mono substituted pyrozole, 4-Bromopyrazole can be used as Inhibitor of human liver alcohol dehydrogenase and used in mutagenicity study with the L-arabinose resistance test of Salmonella typhimurium.

General Description

4-Bromopyrazole is a pyrazole derivative. It is reported to react with titanium tetrachloride to afford binary adducts. Mutagenicity of 4-bromopyrazole has been tested using the L-arabinose forward mutation assay of Salmonella typhimurium. It is reported to inhibit the oxidative phosphorylation, the ATP^-32P exchange reaction, and energy dependent and independent calcium uptake.

Synthesis

288-13-1

2075-45-8

Step 1: 1H-pyrazole (10 g, 147 mmol) was suspended in water (150 mL) at room temperature and N-bromosuccinimide (NBS, 26.1 g, 147 mmol) was added all at once. The reaction mixture immediately turned milky white, followed by continuous stirring at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (EtOAc, 2 x 100 mL). The combined organic phases were washed sequentially with aqueous sodium carbonate (Na2CO3) and saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After concentration under reduced pressure, 21.5 g of light brown oily product (100% yield) was obtained, which solidified to a solid after standing. High performance liquid chromatography (HPLC) analysis showed a main peak retention time (RT) of 0.87 min.

References

[1] Saied M. Soliman, Ahmed M.A. Badr. “Synthesis, structure and Hirshfeld analysis of the potent antimicrobial [Ag(4-bromopyrazole)2ClO4] complex.” Polyhedron 171 (2019): Pages 323-329.
[2] Shaoling Wang , Hongkun Zhao, Cunbin Du . “Solubility, solution thermodynamics and preferential solvation for 4-bromopyrazole in mixed solvents of (methanol/ethanol+ water) from T = (283.15 to 318.15) K.” Journal of Chemical Thermodynamics 112 (2017): Pages 146-154.

4-Bromopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methyl-4-pyrazole boronic acid pinacol ester

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4-Bromopyrazole Suppliers

Americas 1 Canada 1 China 378 Europe 1 France 1 Germany 2 India 52 Japan 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 8 United States 36 Global 485

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J & K SCIENTIFIC LTD.

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View Lastest Price from 4-Bromopyrazole manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: 4-Bromopyrazole 2075-45-8
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Bromopyrazole 2075-45-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2025-04-30

RongNa Biotechnology Co.,Ltd

Product: 4-Bromopyrazole 2075-45-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-06-25

2075-45-8, 4-BromopyrazoleRelated Search:

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4-bromo-pyrazol

4-Brompyrazole

Pyrazole, 4-bromo-

4-BROMO-1H-PYRAZOLE

4-BROMOPYRAZOLE

AKOS B001462

93℃-96℃

4-Bromopyrazole,98%

4-bromo-1H-pyrazole(SALTDATA: FREE)

Crizotinib Impurity 13

4-Bromo-1H-pyrazole 99%

NSC 522023

1H-Pyrazole, 4-broMo-

4-BroMo-1H-pyrazole, 98+%

4 - broMine pyrazole

4-Bromopyrazole 4-Bromo-1H-pyrazole

1H-Pyrazole, 4-bromo- (9CI)

WLN: T5MNJ DE

4-Bromopyrazole &gt

Baricitinib-001

4-Bromo-1H-pyrazole Discontinued See B687110

2-mercapto-4 - (4-pyridyl) thiazole

TIANFU-CHEM best supplier 4-Bromo-pyrazole 2075-45-8

DK660

2075-45-8

2074-45-8

C3H3BrN2

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2075-45-8