3-BROMO-1H-PYRAZOLE
- Product Name
- 3-BROMO-1H-PYRAZOLE
- CAS No.
- 14521-80-3
- Chemical Name
- 3-BROMO-1H-PYRAZOLE
- Synonyms
- 3-Bromopyrazole 97%;MFCD13189492;3-BROMO-PYRAZOLE;3-BROMO-1H-PYRAZOLE;3-bromo-2H-pyrazole;1H-PYRAZOLE, 3-BROMO-;1H-Pyrazole,3-bromo-(9CI);3-Bromo-1H-Pyrazole(WX900043);3-Bromopyrazole/3-broMo-1H-pyrazole
- CBNumber
- CB1121665
- Molecular Formula
- C3H3BrN2
- Formula Weight
- 146.97
- MOL File
- 14521-80-3.mol
3-BROMO-1H-PYRAZOLE Property
- Melting point:
- 60-65°C
- Boiling point:
- 70-72 °C(Press: 0.1 Torr)
- Density
- 1.904±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- crystals
- pka
- 10.88±0.10(Predicted)
- color
- White-pale yellow
- InChI
- InChI=1S/C3H3BrN2/c4-3-1-2-5-6-3/h1-2H,(H,5,6)
- InChIKey
- XHZWFUVEKDDQPF-UHFFFAOYSA-N
- SMILES
- N1C=CC(Br)=N1
- CAS DataBase Reference
- 14521-80-3
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 1
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 723924
- Product name
- 3-Bromopyrazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $170
- Updated
- 2025/07/31
- Product number
- 723924
- Product name
- 3-Bromopyrazole
- Purity
- 97%
- Packaging
- 500mg
- Price
- $123
- Updated
- 2023/06/20
- Product number
- B687345
- Product name
- 3-Bromopyrazole
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 067227
- Product name
- 3-Bromopyrazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CAPOB13736
- Product name
- 3-Bromo-1H-pyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
3-BROMO-1H-PYRAZOLE Chemical Properties,Usage,Production
Uses
3-Bromopyrazole is a useful synthetic intermediate in the synthesis of Rynaxypyr (C325380); an insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
Synthesis
500011-84-7
14521-80-3
General procedure for the synthesis of 3-bromopyrazole from 1-(dimethylaminosulfonyl)-3-bromopyrazole: 3-bromo-N,N-dimethyl-1H-pyrazole-1-sulfonamide (5.83 g) obtained in step B was mixed with trifluoroacetic acid (9.0 mL) and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, ethyl acetate was added to the mixture, followed by neutralization of the reaction solution with saturated aqueous sodium bicarbonate and washing with saturated aqueous sodium chloride. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to give the final target compound 3-bromopyrazole (2.92 g). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.37 (1H, d, J=2.4 Hz), 7.57 (1H, d, J=2.4 Hz).
References
[1] Patent: WO2006/68669, 2006, A1. Location in patent: Page/Page column 19; 24
[2] Patent: WO2003/106427, 2003, A2. Location in patent: Page 18
[3] Patent: WO2004/11447, 2004, A2. Location in patent: Page 42-43
[4] Patent: EP2818473, 2014, A1. Location in patent: Paragraph 0583
[5] Patent: US9113630, 2015, B2. Location in patent: Page/Page column 41; 42
3-BROMO-1H-PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
3-BROMO-1H-PYRAZOLE Suppliers
- Tel
- 13816002113
- Fax
- -
- 68249111@qq.com
- Country
- China
- ProdList
- 70
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 15262370735
- 404840704@qq.com
- Country
- China
- ProdList
- 109
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1370
- Advantage
- 59
View Lastest Price from 3-BROMO-1H-PYRAZOLE manufacturers
- Product
- 3-BROMO-1H-PYRAZOLE 14521-80-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- 3-Bromo-1H-pyrazole 14521-80-3
- Price
- US $130.00-850.00/g
- Min. Order
- 1g
- Purity
- 99.2%
- Supply Ability
- 20tons
- Release date
- 2019-12-31
- Product
- 3-BROMO-1H-PYRAZOLE 14521-80-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-19