4-Bromo-3,5-dimethylpyrazole

Product Name: 4-Bromo-3,5-dimethylpyrazole
CAS No.: 3398-16-1
Chemical Name: 4-Bromo-3,5-dimethylpyrazole
Synonyms: GF 12;AKOS B001459;AKOS PAO-1351;BUTTPARK 47\04-31;VITAS-BB TBB000654;IFLAB-BB F0900-0030;Bromo-3,5-dimethylpyrazole;4-BROMO-3,5-DIMETHYLPYRAZOLE;4-bromo-3,5-dimethyl-pyrazol;3,5-Dimethyl-4-bromoisoxazole
CBNumber: CB4402295
Molecular Formula: C5H7BrN2
Formula Weight: 175.03
MOL File: 3398-16-1.mol

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4-Bromo-3,5-dimethylpyrazole Property

Melting point:: 123-125 °C(lit.)
Boiling point:: 269.1±35.0 °C(Predicted)
Density: 1.595
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 13.83±0.50(Predicted)
color: White to Light yellow
BRN: 108534
InChI: InChI=1S/C5H7BrN2/c1-3-5(6)4(2)8-7-3/h1-2H3,(H,7,8)
InChIKey: RISOHYOEPYWKOB-UHFFFAOYSA-N
SMILES: N1C(C)=C(Br)C(C)=N1
CAS DataBase Reference: 3398-16-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: UQ6210000
HazardClass: IRRITANT
HS Code: 29331990
Toxicity: LD50 intraperitoneal in mouse: 580mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3306
Product name: 4-Bromo-3,5-dimethylpyrazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B3306
Product name: 4-Bromo-3,5-dimethylpyrazole
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $67
Updated: 2025/07/31

TRC

Product number: B691728
Product name: 4-Bromo-3,5-dimethylpyrazole
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B691728
Product name: 4-Bromo-3,5-dimethylpyrazole
Packaging: 5g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 017107
Product name: 4-Bromo-3,5-dimethyl-1H-pyrazole
Purity: 98%
Packaging: 1g
Price: $11
Updated: 2021/12/16

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4-Bromo-3,5-dimethylpyrazole Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

4-Bromo-3,5-dimethylpyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

67-51-6

3398-16-1

The general procedure for the synthesis of 3,5-dimethyl-4-bromopyrazole from 3,5-dimethylpyrazole is as follows: 1. In a 16 mL vial, 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol), a magnetic stir bar, 0.7 mL of water, and 0.3 mL of ethyl acetate were added. 2. NaCl (123 mg, 2 mmol) was added and the vial was placed in a room temperature water bath to control the exothermic nature of the reaction. 3. Oxone (322 mg, 0.52 mmol or 1.05 mmol KHSO5) was added and the vial was capped. 4. React under continuous vigorous stirring until thin layer chromatography (TLC) analysis (1 hr) showed complete consumption of the raw material. 5. Reduce the remaining oxidizing agent using solid sodium bisulfite until the starch iodide paper tests negative. 6. Water (5 mL) was added and the reaction mixture was extracted with a 1:1 hexane/ether solvent mixture (3 x 5 mL). 7. The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give the crude product. 8. The crude product was purified by fast chromatography (14 x 1 cm, eluent 9:1 hexane/ethyl acetate) to afford pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole as a light yellow oil (215 mg, 93% yield).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 40, p. 6833 - 6837
[2] Chemical & Pharmaceutical Bulletin, 1988, vol. 36, # 10, p. 3838 - 3848
[3] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4111 - 4114
[4] Canadian Journal of Chemistry, 1992, vol. 70, # 4, p. 1121 - 1128
[5] Journal of the Chemical Society, 1923, vol. 123, p. 1315

4-Bromo-3,5-dimethylpyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3,5-dimethylpyrazole Suppliers

Americas 1 Belgium 2 Canada 1 China 175 Europe 1 Germany 3 India 6 Japan 1 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 12 United States 29 Global 234

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View Lastest Price from 4-Bromo-3,5-dimethylpyrazole manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 4-Bromo-3,5-dimethylpyrazole 3398-16-1
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-3,5-dimethylpyrazole 3398-16-1
Price: US $10.00-8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-05

Hubei Lidu New Material Technology Co., Ltd

Product: 4-Bromo-3,5-dimethylpyrazole 3398-16-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20TON
Release date: 2024-12-11

3398-16-1, 4-Bromo-3,5-dimethylpyrazoleRelated Search:

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4-BROMO-3,5-DIMETHYL-1H-PYRAZOLE

4-BROMO-3,5-DIMETHYLPYRAZOLE

AKOS B001459

AKOS PAO-1351

VITAS-BB TBB000654

IFLAB-BB F0900-0030

BUTTPARK 47\04-31

4-bromo-3,5-dimethyl-pyrazol

3,5-Dimethyl-4-bromoisoxazole

4-Bromo-3,5-dimethylpyrazole,99%

3.5-Dimethyl-4-bromo pyrazole

3,5- two Methylpyrazole-4-broMide

3,5- two-4- MethylbroMidepyrazole

3, 5 - diMethyl - 4 - broMine pyrazole

4-Bromo-3,5-dimethyl-1H-pyrazole,99%

GF 12

Pyrazole, 4-bromo-3,5-dimethyl-

4-Bromo-3,5-dimethylpyrazole &gt

1H-Pyrazole, 4-bromo-3,5-dimethyl-

4-BROMO-3,5-DIMETHYLPYRAZOLE 3398-16-1

Bromo-3,5-dimethylpyrazole

3398-16-1

C5H7BrN2

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrazoles

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C3 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Halides

Pyrazoles & Triazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrazoles

PyrazolesHeterocyclic Building Blocks

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