(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Product Name
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- CAS No.
- 877397-70-1
- Chemical Name
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Synonyms
- Crizotinib Impurity 7;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitropyridine;3-[[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-2-nitropy...;Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro-;3-[[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-2-nitropyridine;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB02520753
- Molecular Formula
- C13H9Cl2FN2O3
- Formula Weight
- 331.13
- MOL File
- 877397-70-1.mol
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine Property
- Density
- 1.474
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 877397-70-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-M0264
- Product name
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Packaging
- 100mg
- Price
- $171
- Updated
- 2021/12/16
- Product number
- CS-M0264
- Product name
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Packaging
- 250mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- 3953AC
- Product name
- (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CCH0032876
- Product name
- (R)-3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-2-NITROPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.24
- Updated
- 2021/12/16
- Product number
- CS-M0264
- Product name
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
- Packaging
- 1g
- Price
- $731
- Updated
- 2021/12/16
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine Chemical Properties,Usage,Production
Synthesis
15128-82-2
877397-65-4
877397-70-1
Step 1: (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (20.9 g, 0.10 mol) was dissolved in anhydrous tetrahydrofuran (200 mL) under nitrogen protection. Subsequently, 3-hydroxy-2-nitropyridine (16.0 g, 0.11 mol) and triphenylphosphine (40.0 g, 0.15 mol) were added sequentially and stirred at room temperature for 1 hour. The reaction system was cooled to 0 °C and diisopropyl azodicarboxylate (DIAD, 40 mL, 0.15 mol) was added slowly and the reaction continued to stir for 12 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to obtain the crude product. Purification by silica gel column chromatography afforded the target product (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (20.2 g, 61% yield).
References
[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 20
[2] Patent: WO2006/21886, 2006, A1. Location in patent: Page/Page column 51
[3] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1018 - 1026
[4] Patent: CN105348265, 2016, A. Location in patent: Paragraph 0056; 0057; 0058
[5] Patent: CN103664896, 2016, B. Location in patent: Paragraph 0108; 0109
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine manufacturers
- Product
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 877397-70-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-05-08
- Product
- Crizotinib Impurity 3 877397-70-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-25
- Product
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 877397-70-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16