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ChemicalBook > CAS DataBase List > 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE

5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE

Application
Product Name
5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
CAS No.
91476-80-1
Chemical Name
5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
Synonyms
5,6,7,8-Tetrahydroimidazo...;5H,6H,7H,8H-iMidazo[1,2-a]pyrazine;5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE;tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine;Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-;5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine95%;5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine 95%;5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine hcl;5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
CBNumber
CB51504139
Molecular Formula
C6H9N3
Formula Weight
123.16
MOL File
91476-80-1.mol
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5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Property

Boiling point:
322.8±35.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
7.91±0.20(Predicted)
form 
solid
color 
Yellow
InChI
InChI=1S/C6H9N3/c1-3-9-4-2-8-6(9)5-7-1/h2,4,7H,1,3,5H2
InChIKey
SWBUHQQTIPEPMK-UHFFFAOYSA-N
SMILES
C12=NC=CN1CCNC2
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
H325653
Product name
5H,6H,7H,8H-imidazo[1,2-a]pyrazine
Packaging
100mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-Q3
Product name
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
Packaging
250mg
Price
$138
Updated
2021/12/16
Matrix Scientific
Product number
072574
Product name
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
Purity
97%
Packaging
1g
Price
$196
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-Q3
Product name
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
Packaging
1g
Price
$234
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
CAPOD11381
Product name
5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine
Purity
92%
Packaging
500mg
Price
$325
Updated
2021/12/16
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5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Usage,Production

Application

Imidazolo[1,2-a]pyrazine is a synthetic building block with strong pharmacological activity among nitrogen-containing heterocyclic compounds. 5,6,7,8-Tetrahydroimidazole[1,2-A]pyrazine is a common pharmaceutical and chemical intermediate used in laboratory research and development processes.

Synthesis

274-79-3

91476-80-1

The general procedure for the synthesis of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine from indolo[1,2-A]pyrazine was as follows: imidazo[1,2-a]pyrazine (7.2 g, 60.44 mmol) was dissolved in 2-methoxyethanol (100 mL). Platinum (IV) oxide (1.2 g, 5.13 mmol) was added to the solution and the mixture was transferred to an autoclave. The reaction mixture was stirred overnight at room temperature and 4 bar hydrogen pressure. Upon completion of the reaction, the hydrogen in the autoclave was replaced with nitrogen and the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and co-evaporated with toluene to remove residual solvent. Finally, the target product 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was purified by column chromatography using a methanol solution of dichloromethane/7N ammonia (95:5, v/v) as eluent to give the target product 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine in a yield of 5.7 g (76% yield).

References

[1] Journal of Chemical Research, Miniprint, 1984, # 2, p. 468 - 480
[2] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 67
[3] Patent: CN103864799, 2016, B. Location in patent: Paragraph 0032 - 0335
[4] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0089; 0091
[5] Patent: US2013/131068, 2013, A1. Location in patent: Paragraph 0117; 0118

5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Suppliers

China 122 Germany 1 India 3 United Kingdom 1 United States 19 Global 146
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View Lastest Price from 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE manufacturers

Career Henan Chemical Co
Product
5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE 91476-80-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

91476-80-1, 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINERelated Search:

5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRAZINE HYDROCHLORIDE 2-Phenyl-imidazo[1,2,a]-4-piperidine ETHYL 3-CHLORO-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE,ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride,2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE 7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE 3-BROMO-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINEHYDROCHLORIDE 7-(TERT-BUTOXYCARBONYL)-3-CHLORO-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE 7-tert-butyl 2-ethyl 3-bromo-5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid methyl ester,METHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE TERT-BUTYL 3-BROMO-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZINE-7(8H)-CARBOXYLATE 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE 0.5 HYDRATE ETHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE DIHYDROCHLORIDE HEMIHYDRATE 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRAZINE DIHYDROCHLORIDE Imidazo[1,2-a]pyrazin-8(5H)-one, 6,7-dihydro- (9CI) 1-BROMO-5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRAZINE HYDROCHLORIDE

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  • 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine 95%
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  • 91476-80-1
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