2,8-DIAZASPIRO[4.5]DECAN-3-ONE
- Product Name
- 2,8-DIAZASPIRO[4.5]DECAN-3-ONE
- CAS No.
- 561314-57-6
- Chemical Name
- 2,8-DIAZASPIRO[4.5]DECAN-3-ONE
- Synonyms
- 2,8-Diazaspiro[4.5]decan-...;2,8-DIAZASPIRO[4.5]DECAN-3-ONE;3,8-Diazaspiro[4.5]decan-2-one HCl;2,8-Diazaspiro[4.5]decan-3-one 95+%;2,8-Diazaspiro[4.5]decan-3-one - [D6100];2,8-Diazaspiro[4.5]decan-3-one (9CI, ACI);2,8-diazaspiro[4.5]decan-3-one(SALTDATA: 2HCl)
- CBNumber
- CB51516808
- Molecular Formula
- C8H14N2O
- Formula Weight
- 154.21
- MOL File
- 561314-57-6.mol
2,8-DIAZASPIRO[4.5]DECAN-3-ONE Property
- Boiling point:
- 360.1±42.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 16.29±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- FD122800
- Product name
- 2,8-Diazaspiro[4.5]decan-3-one trifluoroacetate
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- D6100
- Product name
- 2,8-Diazaspiro[4.5]decan-3-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD122800
- Product name
- 2,8-Diazaspiro[4.5]decan-3-one trifluoroacetate
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- AS51117-A
- Product name
- 2,8-Diazaspiro[4.5]decan-3-one
- Purity
- 97+%
- Packaging
- 1g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 4H48-1-68
- Product name
- 2,8-Diazaspiro[4,5]decan-3-one
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
2,8-DIAZASPIRO[4.5]DECAN-3-ONE Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
169206-67-1
561314-57-6
Tert-butyl 3-oxo-2,8-diazaspiro[4,5]decane-8-carboxylate (920 mg, 3.62 mmol) was used as a raw material and dissolved in a solvent mixture (5 mL / 5 mL) of dichloromethane (DCM) and trifluoroacetic acid (TFA). The reaction mixture was stirred at 30 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 1:1) to confirm that the reaction was complete. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was dissolved in water (30 mL) and the pH was adjusted to 10 with 1N sodium hydroxide solution. subsequently, extraction was performed with dichloromethane (15 mL x 4). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound 2,8-diazaspiro[4.5]decan-3-one (550 mg, 98% yield) as a yellow oil.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2288 - 2294
[2] Patent: CN105330698, 2016, A. Location in patent: Paragraph 0232; 0233; 0234; 0235
2,8-DIAZASPIRO[4.5]DECAN-3-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,8-DIAZASPIRO[4.5]DECAN-3-ONE manufacturers
- Product
- 2,8-DIAZASPIRO[4.5]DECAN-3-ONE 61314-57-6
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23
- Product
- 2,8-DIAZASPIRO[4.5]DECAN-3-ONE 561314-57-6
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23