ChemicalBook > CAS DataBase List > adoprazine

adoprazine

Product Name: adoprazine
CAS No.: 222551-17-9
Chemical Name: adoprazine
Synonyms: SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;Adoprazine, 10 mM in DMSO;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-;1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine
CBNumber: CB51518488
Molecular Formula: C24H24FN3O2
Formula Weight: 405.46
MOL File: 222551-17-9.mol

Less

adoprazine Property

Boiling point:: 565.0±50.0 °C(Predicted)
Density: 1.256
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 6.07±0.10(Predicted)
color: Light yellow to yellow

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 10mg
Price: $408
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001417
Product name: ADOPRAZINE
Purity: 95.00%
Packaging: 5MG
Price: $424.6
Updated: 2021/12/16

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 50mg
Price: $1080
Updated: 2021/12/16

Crysdot

Product number: CD31002621
Product name: Adoprazine
Purity: 98+%
Packaging: 5mg
Price: $400
Updated: 2021/12/16

Less

adoprazine Chemical Properties,Usage,Production

Uses

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].

Biological Activity

Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.

in vitro

Adoprazine (SLV313) has high affinity at human recombinant D ₂ , D ₃ , D ₄ , 5-HT < sub> 2B , and 5-HT _1A receptors, with pK _i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D ₂ receptor antagonist and an efficacious serotonin 5-HT _1A receptor agonist, with E _{max value (% effect of 10 μM 5-HT) of 73 and pK _B value of 8.5 .}

in vivo

Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.

Animal Model:	Male Wistar rats (275-350 g)
Dosage:	0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	po; single
Result :	Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

target

5-HT _1A Receptor

9 (pEC ₅₀ )

D _{2 < /sub> Receptor}

9.3 (pA2)

D _{3 Receptor}

8.9 (pA2)

D ₄ Receptor

8.0 (pKi)

5-HT _{7 Receptor}

7.2 (pKi)

5-HT _{1A < /sub> Receptor}

9.1 (pKi)

D _{2 Receptor}

8.4 (pKi)

D ₃ Receptor

8.4 (pKi)

IC 50

5-HT_1A Receptor: 9 (pEC₅₀); D₂ Receptor: 9.3 (pA2); D₃ Receptor: 8.9 (pA2); D₄ Receptor: 8.0 (pKi); 5-HT₇ Receptor: 7.2 (pKi); 5-HT_1A Receptor: 9.1 (pKi); D₂ Receptor: 8.4 (pKi); D₃ Receptor: 8.4 (pKi)

References

[1] Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. DOI:10.1038/sj.npp.1301098
[2] Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70. DOI:10.1016/j.ejphar.2006.01.027

adoprazine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

adoprazine Suppliers

China 46 United States 10 Global 56

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Auonsi (Shanghai) Biology Technology Co., Ltd.

Tel: 400-1107768 15058188853
Fax: 0571-88150696
Email: 478133536@qq.com
Country: China
ProdList: 8552
Advantage: 58

Shanghai Zunlijia Life Technology Co., Ltd

Tel: 021-34045219 13062664914
Email: huji@zunlijia.com
Country: China
ProdList: 10027
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Guangzhou Boyu Biotechnology Co., Ltd.

Tel: 18819212151
Country: CHINA
ProdList: 120
Advantage: 58

Guangzhou Xinghe Biotechnology Co., Ltd.

Tel: 15889822182
Country: CHINA
ProdList: 160
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Rhenbo (Shanghai) Biochemical Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6333
Advantage: 58

Shanghai Qincheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shqcsw01@163.com
Country: CHINA
ProdList: 6821
Advantage: 58

Shanghai Zhenyu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2836767067@qq.com
Country: CHINA
ProdList: 6970
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6757
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Shanghai Lianshuobao is Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: lianshuobio@163.com
Country: CHINA
ProdList: 6984
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6448
Advantage: 58

222551-17-9, adoprazineRelated Search:

Dibenzothiophene DIBENZAZEPINE Phthalan 1,4-Benzodioxan

adoprazine

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine

Unii-7snb18Q89d

SLV 313

SLV313

Adoprazine (SLV313)

SLV 313;SLV313;SLV-313

Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine , Adoprazine

Adoprazine, 10 mM in DMSO

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine

222551-17-9