adoprazine

ChemicalBook > CAS DataBase List > adoprazine

Product Name: adoprazine
CAS No.: 222551-17-9
Chemical Name: adoprazine
Synonyms: SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
CBNumber: CB51518488
Molecular Formula: C24H24FN3O2
Formula Weight: 405.46
MOL File: 222551-17-9.mol

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adoprazine Property

Boiling point:: 565.0±50.0 °C(Predicted)
Density: 1.256
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 6.07±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 10mg
Price: $408
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001417
Product name: ADOPRAZINE
Purity: 95.00%
Packaging: 5MG
Price: $424.6
Updated: 2021/12/16

ChemScene

Product number: CS-0673
Product name: Adoprazine
Purity: 98.10%
Packaging: 50mg
Price: $1080
Updated: 2021/12/16

DC Chemicals

Product number: DC9324
Product name: Adoprazine
Purity: >98%
Packaging: 1g
Price: $3600
Updated: 2021/12/16

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adoprazine Chemical Properties,Usage,Production

Biological Activity

Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.

in vitro

Adoprazine (SLV313) has high affinity at human recombinant D ₂ , D ₃ , D ₄ , 5-HT < sub> 2B , and 5-HT _1A receptors, with pK _i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D ₂ receptor antagonist and an efficacious serotonin 5-HT _1A receptor agonist, with E _{max value (% effect of 10 μM 5-HT) of 73 and pK _B value of 8.5 .}

in vivo

Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.

Animal Model:	Male Wistar rats (275-350 g)
Dosage:	0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	po; single
Result :	Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

target

5-HT _1A Receptor

9 (pEC ₅₀ )

D _{2 < /sub> Receptor}

9.3 (pA2)

D _{3 Receptor}

8.9 (pA2)

D ₄ Receptor

8.0 (pKi)

5-HT _{7 Receptor}

7.2 (pKi)

5-HT _{1A < /sub> Receptor}

9.1 (pKi)

D _{2 Receptor}

8.4 (pKi)

D ₃ Receptor

8.4 (pKi)

adoprazine Preparation Products And Raw materials

Raw materials

Preparation Products

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222551-17-9, adoprazineRelated Search:

Dibenzothiophene DIBENZAZEPINE Phthalan 1,4-Benzodioxan

adoprazine

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine

Unii-7snb18Q89d

SLV 313

SLV313

Adoprazine (SLV313)

SLV 313;SLV313;SLV-313

Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-

222551-17-9