N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

Product Name: N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE
CAS No.: 169457-73-2
Chemical Name: N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE
Synonyms: 1-Boc-4-(2-bromoethyl)piperidine;N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE;4-(2-bromoethyl)piperidine-1-carboxylate;4-(2-Bromoethyl)-1-(tert-butoxycarbonyl)piperidine;4-(2-Bromoethyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester
CBNumber: CB51519425
Molecular Formula: C12H22BrNO2
Formula Weight: 292.21
MOL File: 169457-73-2.mol

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N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Property

Melting point:: 39-42℃
Boiling point:: 334.2±15.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.52±0.40(Predicted)
form: liquid
color: Colourless
InChI: InChI=1S/C12H22BrNO2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9H2,1-3H3
InChIKey: CLBWAEYOPRGKBT-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(CCBr)CC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 097379
Product name: tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $76
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154454
Product name: tert-Butyl4-(2-bromoethyl)piperidine-1-carboxylate
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 097379
Product name: tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity: 95+%
Packaging: 500mg
Price: $116
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154454
Product name: tert-Butyl4-(2-bromoethyl)piperidine-1-carboxylate
Packaging: 250mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 097379
Product name: tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $179
Updated: 2021/12/16

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N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

89151-44-0

169457-73-2

General procedure for the synthesis of N-Boc-4-(2-bromoethyl)piperidine from N-Boc-4-piperidine ethanol: N-Boc-4-(2-hydroxyethyl)piperidine (0.95 g, 4.17 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL), followed by carbon tetrabromide (1.34 g, 4.0 mmol). A solution of triphenylphosphine (1.15 g, 4.38 mmol) in anhydrous tetrahydrofuran (2 mL) was added slowly and dropwise over 2 hours. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, ether (50 mL) was added to the mixture, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio 9:1 hexane:ethyl acetate) to afford the target product N-Boc-4-(2-bromoethyl)piperidine (1.05 g, 86% yield) as an oil.

References

[1] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185
[2] Patent: US2007/32469, 2007, A1. Location in patent: Page/Page column 46
[3] Patent: US2009/192169, 2009, A1. Location in patent: Page/Page column 60
[4] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1666
[5] Patent: WO2008/27521, 2008, A1. Location in patent: Page/Page column 63

N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Suppliers

China 70 India 1 United Kingdom 3 United States 10 Global 84

Accela ChemBio Inc.

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View Lastest Price from N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE manufacturers

Career Henan Chemical Co

Product: N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE 169457-73-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 100kg
Release date: 2020-01-10

169457-73-2, N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINERelated Search:

tert-butyl 4-(2-bromophenoxy)piperidine-1-carboxylate 4-(2-BROMO-PROPYL)-PIPERIDIN-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

4-(2-Bromoethyl)-1-(tert-butoxycarbonyl)piperidine

4-(2-Bromoethyl)piperidine-1-carboxylic acid tert-butyl ester

1-Boc-4-(2-bromoethyl)piperidine

1-Piperidinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester

4-(2-bromoethyl)piperidine-1-carboxylate

169457-73-2