5-NITRO-1,3-BENZOXAZOLE

Product Name: 5-NITRO-1,3-BENZOXAZOLE
CAS No.: 70886-33-8
Chemical Name: 5-NITRO-1,3-BENZOXAZOLE
Synonyms: 5-Nitrobenzoxazole;Benzoxazole, 5-nitro-;5-NITRO-1,3-BENZOXAZOLE
CBNumber: CB5154128
Molecular Formula: C7H4N2O3
Formula Weight: 164.12
MOL File: 70886-33-8.mol

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5-NITRO-1,3-BENZOXAZOLE Property

Melting point:: 127-129°
Boiling point:: 294.2±13.0 °C(Predicted)
Density: 1.473±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -5.69±0.10(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N493588
Product name: 5-Nitro-1,3-benzoxazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V7417
Product name: 5-Nitro-1,3-benzoxazole
Packaging: 1g
Price: $71
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-1-AG
Product name: 5-Nitro-1,3-benzoxazole
Packaging: 1g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-1-AG
Product name: 5-Nitro-1,3-benzoxazole
Packaging: 5G
Price: $56
Updated: 2021/12/16

Matrix Scientific

Product number: 045160
Product name: 5-Nitro-1,3-benzoxazole
Purity: >95%
Packaging: 500mg
Price: $118
Updated: 2021/12/16

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5-NITRO-1,3-BENZOXAZOLE Chemical Properties,Usage,Production

Uses

5-Nitrobenzoxazole is a useful reactant for copper-catalyzed direct carboxylation of C-H bonds in benzoxazoles and related compounds with carbon dioxide.

Synthesis

122-51-0

99-57-0

70886-33-8

To a 50 mL single-necked round-bottomed flask equipped with a magnetic stirrer was added 2-amino-4-nitrophenol (5.0 mmol, 1.0 eq.) and triethyl orthoformate (60.0 mmol, 12.0 eq.). The reaction mixture was slowly heated to 150 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by distillation under reduced pressure to remove the excess triethyl orthoformate and the resulting ethanol by-product. The crude product was purified by silica gel column chromatography to give the final target compound 5-nitrobenzoxazole (see Table S-2).

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11511 - 11515
[2] Journal of the Chinese Chemical Society, 2015, vol. 62, # 5, p. 412 - 419
[3] Tetrahedron, 2013, vol. 69, # 32, p. 6627 - 6633
[4] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 1029 - 1034
[5] Angewandte Chemie - International Edition, 2009, vol. 48, # 48, p. 9127 - 9130

5-NITRO-1,3-BENZOXAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-NITRO-1,3-BENZOXAZOLE Suppliers

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70886-33-8, 5-NITRO-1,3-BENZOXAZOLERelated Search:

Methyl 4-(5'-nitro-6'-hydroxylbenzoxazol-2-yl)benzate 5-NITRO-1,3-BENZOXAZOLE 2-BUTYL-5-NITRO-1,3-BENZOXAZOLE 5-NITRO-2-PROPYL-1,3-BENZOXAZOLE 2-ETHYL-5-NITRO-1,3-BENZOXAZOLE 2-(CHLOROMETHYL)-5-NITRO-1,3-BENZOXAZOLE 5-Nitrobenzoxazole-2-amine 2-METHYL-5-NITRO-1,3-BENZOXAZOLE AKOS BB-9364 AKOS BB-9294 2-(4-CHLOROPHENYL)-5-NITROBENZO[D]OXAZOLE 2-(3,5-DICHLOROPHENYL)-5-NITROBENZO[D]OXAZOLE N-(5-NITRO-1,3-BENZOXAZOL-2-YL)GUANIDINE 5-Nitro-2-thiomethyl benzoxazole 3-(5-NITROBENZO[D]OXAZOL-2-YL)PHENOL AKOS BB-9300 5-NITRO-1,3-BENZOXAZOLE-2-THIOL 4-(5-NITROBENZO[D]OXAZOL-2-YL)PHENOL

5-Nitrobenzoxazole

5-NITRO-1,3-BENZOXAZOLE

Benzoxazole, 5-nitro-

70886-33-8