5-Nitrobenzoxazole-2-amine
- Product Name
- 5-Nitrobenzoxazole-2-amine
- CAS No.
- 64037-16-7
- Chemical Name
- 5-Nitrobenzoxazole-2-amine
- Synonyms
- 5-Nitro-2-benzoxazolamine;5-Nitrobenzoxazole-2-amine;2-Amino-5-nitrobenzoxazole;2-Benzoxazolamine, 5-nitro-;5-nitro-benzooxazol-2-ylamine;2-Amino-5-nitro-1,3-benzoxazole;5-Nitro-1,3-benzoxazol-2-amine, 2-Amino-5-nitrobenzo[d]oxazole
- CBNumber
- CB52400612
- Molecular Formula
- C7H5N3O3
- Formula Weight
- 179.13
- MOL File
- 64037-16-7.mol
5-Nitrobenzoxazole-2-amine Property
- Melting point:
- 288 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 387.6±34.0 °C(Predicted)
- Density
- 1.575±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -3.44±0.10(Predicted)
- Appearance
- Light yellow to green yellow Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N497965
- Product name
- 5-Nitro-1,3-benzoxazol-2-amine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 9813AB
- Product name
- 5-Nitrobenzo[d]oxazol-2-amine
- Packaging
- 1g
- Price
- $301
- Updated
- 2021/12/16
- Product number
- 9813AB
- Product name
- 5-Nitrobenzo[d]oxazol-2-amine
- Packaging
- 5g
- Price
- $686
- Updated
- 2021/12/16
- Product number
- CHM0102183
- Product name
- 5-NITRO-1,3-BENZOXAZOL-2-AMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $852.55
- Updated
- 2021/12/16
- Product number
- CHM0102183
- Product name
- 5-NITRO-1,3-BENZOXAZOL-2-AMINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
5-Nitrobenzoxazole-2-amine Chemical Properties,Usage,Production
Synthesis
127099-85-8
99-57-0
64037-16-7
General method: 2-Amino-4-nitrophenol (1 eq.) and cyanoguanidine (3 eq.) were dissolved in 1,4-dioxane (30 mL/g 2-amino-4-nitrophenol), followed by the addition of boron trifluoride diethyl ether compound (3.0 eq.). The reaction system was heated under argon protection at 80 °C and the reaction progress was monitored by TLC (5-16 h). Upon completion of the reaction, the reaction mixture was cooled and quenched with saturated aqueous sodium bicarbonate (100 mL/g 2-amino-4-nitrophenol) and subsequently extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Depending on the purity of the crude product, the residue can be purified by washing with ethyl acetate, acetone or other suitable organic solvents or by rapid chromatography on silica gel (eluent: cyclohexane/ethyl acetate, gradient from 100/0 to 0/100, v/v) to afford the target product 5-nitrobenzo[d]oxazol-2-amine. The physical properties of the obtained compounds were in agreement with the data reported in the literature.
References
[1] Tetrahedron Letters, 2018, vol. 59, # 17, p. 1642 - 1645
5-Nitrobenzoxazole-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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