Acute toxicity
ChemicalBook > CAS DataBase List > (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE

(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE

Acute toxicity
Product Name
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
CAS No.
64285-06-9
Chemical Name
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
Synonyms
Antx-a;anatoxini;Anatoxin 1;Brn 5477454;(1r)-ethanon;(-)-Anatoxin;(+)-Anatoxin-a;(+/-)-ANATOXIN A;(+/-)-ANATOXIN A FUMERATE;(+/-)-ANATOXIN A FUMARATE
CBNumber
CB5154476
Molecular Formula
C10H15NO
Formula Weight
165.23
MOL File
64285-06-9.mol
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(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Property

alpha 
D25 +39.8°
Boiling point:
293.09°C (rough estimate)
Density 
1.0203 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Desiccate at +4°C
pka
9.4(at 25℃)
form 
White solid.
color 
Oil
EPA Substance Registry System
Ethanone, 1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl- (64285-06-9)
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Safety

Hazardous Substances Data
64285-06-9(Hazardous Substances Data)
Toxicity
LD50 i.p. in mice: 200 mg/kg (Carmichael)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
TOX0000576
Product name
(+/-)-ANATOXIN A
Purity
95.00%
Packaging
5MG
Price
$505.04
Updated
2021/12/16
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(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Chemical Properties,Usage,Production

Acute toxicity

Intraperitoneal-mouse LDL0: 0.25 mg/kg

Occurrence

An oily alkaloid, anatoxin-a has been isolated from Anabaena jfos-aquae.

Uses

(+)-Anatoxin-a is a secondary, bicyclic amine alkaloid and cyanotoxin with acute neurotoxicity. The toxin is produced by at least four different genera of cyanobacteria and has been reported in North America, Europe, Africa, Asia, and New Zealand. Symptoms of anatoxin exposure are loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 4539, 1984 DOI: 10.1021/ja00328a040

Biological Activity

A potent nicotinic agonist (K i values are 1.25 and 1840 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Stimulates [ 3 H]-dopamine release from rat striatal synaptosomes (EC 50 = 136 nM).

Safety Profile

Poison by intraperitoneal route.An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.

(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Suppliers

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64285-06-9, (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATERelated Search:


  • (1r)-ethanon
  • anatoxini
  • (+/-)-ANATOXIN A
  • (+/-)-ANATOXIN A FUMARATE
  • (+/-)-ANATOXIN A FUMERATE
  • (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
  • (-)-Anatoxin
  • (1β,6β)-5-Acetyl-9-azabicyclo[4.2.1]non-4-ene
  • [1S,6S,(-)]-2-Acetyl-9-azabicyclo[4.2.1]non-2-ene
  • (1R,6R)-2-Acetyl-9-azabicyclo[4.2.1]non-2-ene
  • Anatoxin 1
  • Antx-a
  • Brn 5477454
  • Ethanone, 1-(1R,6R)-9-azabicyclo(4.2.1)non-2-en-2-yl-
  • Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)-
  • (+)-Anatoxin-a
  • (+)-Anatoxin A DISCONTINUED. Please see A653360.
  • (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
  • 64285-06-9
  • C10H15NOC4H4O4
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Nicotinic
  • Acetylcholine receptor